Associate Director/Director, Precision Oncology

4 weeks ago

Cambridge, Massachusetts, United States Flagship Ventures Full time
Job Title: Associate Director/Director, Precision Oncology

Flagship Pioneering's venture creation engine has conceived and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Sana Biotechnology (NASDAQ: SANA), Generate Biomedicines, and Tessera Therapeutics. We are seeking a talented and highly motivated Associate Director/Director Oncology to play a vital role in the company's efforts to progress lead candidates to IND and early clinical studies.

Key Responsibilities:
  • Design, plan, and implement high-quality in vitro and in vivo assays.
  • Lead target validation activities, including target assessment, prioritization, and the development and execution of workplans.
  • Design and implement in vitro assays to evaluate the mechanisms of action of the target.
  • Plan and execute animal studies by coordinating with external research vendors, defining tissue and disease-specific target engagement levels, and establishing biomarker plans and translational PK/PD assessments.
  • Lead cross-functional project teams to design, plan, and execute experimental studies, ensuring milestones and objectives are met within established timelines.
Requirements:
  • Ph.D. in Cancer Biology, Immunology, or a related discipline with 8 - 10 years of experience in a biotech or pharmaceutical company.
  • Comprehensive knowledge and understanding of tumor intrinsic mechanisms (oncogenic drivers, cancer vulnerabilities) and target validation for drug discovery.
  • Proven experience in screening and prioritizing targets derived from target identification efforts.
  • Extensive hands-on experience in mammalian cell culture, including primary cells and tissue handling.
  • Proficiency in designing and executing tumor animal models, as well as conducting pharmacokinetic (PK) and pharmacodynamic (PD) analyses.
What We Offer:
  • A dynamic and cross-functional team environment.
  • A fast-paced entrepreneurial environment.
  • Opportunities for professional growth and development.

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