Senior Scientist X-Ray Crystallography Expert

7 days ago

Reston, Virginia, United States Pledge Therapeutics Full time

Job Title: Senior Scientist Structural Biologist | X-Ray Crystallography

Location: Greater Boston

About the Company: Pledge Therapeutics is a pioneering biotech firm dedicated to advancing treatments in immunology and virology. We are passionate about developing novel therapies addressing unmet medical needs in immune-oncology and viral infections. Leveraging our cutting-edge discovery platform, we have developed high-quality medicinal leads for multiple exciting drug targets that can potentially revolutionize existing treatment paradigms. Our breakthrough discoveries are ready to be transitioned from the lab to the clinic.

About the Role: We seek an exceptional scientist capable of tackling the challenges associated with leading-edge discoveries. The successful candidate will integrate into an international and multidisciplinary team of scientists, engage in different research areas, and work cross-functionally with the IO and Virology team to leverage crystallography to solve key molecular structures, produce high-quality proteins, and contribute to the development and advancement of novel therapeutic strategies. This scientist is the driving force behind our R&D efforts, capable of adapting to any situation and responding swiftly to changing conditions. From urgent research studies to critical experiments, this team member executes efficiently and effectively.

Responsibilities:

  • Leverage crystallography expertise to solve crystal structures of key targets/molecules, including protein crystallography, initial screening, crystal quality optimization, data collection, and structure determination
  • Collaborate with IO / Virology teams to produce proteins, including designing the methodology and performing the purification of proteins of therapeutic interest to provide high-quality material for the advancement of drug discovery campaigns
  • Work with biologists, biophysicists, biochemists, structural biologists, and medicinal chemists to develop comprehensive approaches to ensure target viability and address specific project needs
  • Establish protocols to characterize target proteins for small molecule

Qualifications:

  • Master / PhD degree in Structural Biology / Protein Biochemistry
  • 3-5 years of work experience as a bench scientist in industry (e.g., biotech, pharma)
  • Experience in protein purification for different expression systems using multiple techniques
  • Preference will be given to candidates who have direct experience in enzymology and crystallization techniques (co-crystallization, seeding, cross-seeding, soaking, harvesting, and freezing)
  • Familiar with chemistry and protein computational techniques
  • Champion a "can-do" attitude and flexibility to adjust as R&D priorities shift

Job Type: Full-time, Work Permit, Equal Opportunity Employment

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