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Liquid Handling Automation Specialist
2 months ago
Job Title:
Automation Scientist
Location:
San Diego, CA
Pay Range:
$40 - $43.35/hr
Type:
Contract, Potential for extension or conversion to permanent
Overview
We are seeking a highly qualified automation scientist with a robust background in liquid handling robotics and the integration of supporting technologies. The successful candidate will exhibit innovative strategies in the design, optimization, and execution of Next-Generation Sequencing (NGS) or cell- and organoid-based workflows utilizing automated robotic systems.
This position provides an opportunity to develop expertise in cutting-edge automation technologies while fostering a growth mindset. The candidate will conduct experiments, including scale-down, high-throughput, and automation processes, aimed at enhancing screening capabilities in patient-derived organoid model systems for early drug target discovery.
This role allows for collaboration with diverse cross-functional scientific teams, contributing to pioneering drug discoveries that have a direct impact on patient health.
Key Responsibilities
Integrate Liquid Handling Robotics:
Effectively incorporate liquid handling robotics (such as Beckman-Coulter Biomek i7 & Dynamic Devices Lynx) with complementary instrumentation to perform molecular and cellular biology and organoid workflows.
Automate Standardized Assays:
Validate and implement automated workflows for various standardized assays, including DNA/RNA purification, NGS library preparation, qPCR, cell and organoid passaging, cell/organoid media changes, cell-based viability assays, high-content cell imaging, and sample normalization.
Collaborate and Translate Benchtop Processes:
Work closely with scientists to convert benchtop processes into fully automated workflows, which includes programming/scripting stepwise protocols and rigorously validating processes through dry and wet runs.
Design User-Friendly Processes:
Develop and validate comprehensive processes on integrated lab automation platforms, focusing on user-friendly design, robust execution, and secure data management.
Troubleshoot and Enhance Efficiency:
Engage in advanced experimental troubleshooting alongside scientists to improve usability, process efficiency, and scientific integrity.
Cross-Functional Collaboration:
Collaborate with interdisciplinary teams to integrate NGS and organoid workflows into automated liquid handling systems, ensuring project success.
Technical Troubleshooting:
Address technical and instrument-related issues concerning automation, NGS, and cell-based workflows.
User Training:
Provide training to end-users on automated platform usage (Beckman-Coulter Biomek i7, Dynamic Devices Lynx, Analytik Jena CyBio FeliX) and workflow execution.
Stay Current with Technology:
Remain informed about advancements in automation technology and emerging methodologies relevant to liquid handling systems.
Independent Workflow Development:
Independently develop novel automated workflows.
Meticulous Record Keeping:
Generate, organize, and maintain comprehensive records of all conducted experiments.
Collaboration and Organization:
Work collaboratively with multiple teams across the organization, supporting and sharing methodologies while aligning efforts and harmonizing experimentation.
Lab and Equipment Management:
Oversee lab and equipment organization and maintenance.
Requirements
Masters degree with 1+ year or Bachelors degree with 3+ years experience in bioengineering or biology with a strong focus on automation platforms & liquid handlers in pharmaceutical, biotechnology companies, or academic/not-for-profit organizations.
Minimum 3 years of hands-on experience programming and troubleshooting liquid handling platforms for high-throughput screening (HTS), as well as NGS- and organoid- or cell-based workflows. Direct experience with laboratory operations and maintenance of common automation instruments used for NGS workflows.
Strong understanding of molecular and cellular biology, including NGS assays (e.g., DNA-seq, RNA-Seq). Demonstrated utilization of these assays in practical settings.
Proven ability to create, follow, and maintain Installation Qualifications (IQ), Operational Qualifications (OQ), Performance Qualifications (PQ) protocols as well as Standard Operating Procedures (SOPs) for lab automation systems. Successfully worked with R&D teams to deliver automation projects.
Effective communication and collaboration skills within a multidisciplinary team environment.
Functional knowledge of at least one high-level programming language (e.g., Python). Additional knowledge in other programming languages (e.g., Perl, R, C++) is a plus.
Experience programming, executing, and troubleshooting workflows using Beckman-Coulter and/or Dynamic Devices liquid handling platforms.
Proficient at organizing multiple concurrent projects and tasks.
Excellent troubleshooting and problem-solving skills.
Rigorous and constant evaluation of own work to maintain high quality.
Preferred Skills
Extensive hands-on experience with high-throughput methods, liquid handlers, and laboratory automation schedulers.
Proficiency in integrating liquid handling systems with supporting instrumentation.
In-depth expertise of end-to-end NGS workflows, with a focus on instrumentation and automation.
Functional understanding of cellular biology, molecular biology, DNA/RNA purification.
Proficiency in Next-Generation Sequencing (NGS) protocols.
Knowledge of automation programming and/or scripting (e.g., Python) for liquid handlers.
Previous experience in manual or automated organoid culture and assay development is a plus.
Benefits
System One offers eligible employees health and welfare benefits coverage options, including medical, dental, vision, spending accounts, life insurance, voluntary plans, and participation in a 401(k) plan.
