Senior Biophysics Researcher
7 hours ago
We are seeking a highly motivated Biophysics Researcher to join our collaborative Biophysics group within the Mass Spectrometry & Biophysics department in Quantitative Biosciences. The Biophysics group is part of a multi-disciplinary team focused on enabling lead identification to advance our drug discovery pipeline across diverse therapeutic areas.
Key Responsibilities- Design, develop and execute biophysical assays supporting all stages of drug discovery with an emphasis on screening, hit validation & hit-to-lead activities.
- Serve as a representative for our department on cross-functional program teams, with accountability for providing an integrated biophysical characterization of screening hits, tool molecules and early leads spanning a range of therapeutic modalities (small molecules, peptides and proteins).
- Contribute to the training, growth and development of scientists within the team, including through a personal lab presence and management of 1-3 direct reports.
- Stay abreast of advancements in the field & drive innovation through technology development, external collaboration & long-range capability planning.
- Foster a high-performance culture of inclusion, collaboration, engagement and self-accountability.
- Promote the external reputation of our department through publications and participating in external symposia (co-organizing, chairing & presenting).
- Post-graduate degree in Biophysics, Biochemistry, Pharmacology or another related field with 7+ years of relevant industry experience: Ph.D. (7+ years), M.Sc. (10+ years) or B.Sc. (15+ years).
- Broad, in-depth knowledge of biophysical techniques integral to drug discovery such as SPR, ITC, MST, spectroscopy and thermal shift assays.
- Demonstrated expertise in the determination of binding kinetics and thermodynamics and their impact on drug action.
- Track record of success advancing hits from screening campaigns into lead optimization and beyond.
- Track record of success as a high-performing member of cross-functional, drug discovery teams.
- Experience performing technology evaluations & making recommendations on investments designed to maintain a leadership position in the field.
- Demonstrated passion for talent development and for championing a diverse and inclusive culture.
- Strong external reputation as evidenced through high-impact publications, presentations, and scientific community engagement.
- Excellent verbal, written and interpersonal communication skills with a proven track-record of maintaining strong relationships with stakeholders.
- Expertise in biochemistry, enzymology and/or protein production (cloning, expression & purification) is advantageous.
- Prior experience with affinity-based screening approaches (FBLD, mRNA-display, DNA encoded libraries, affinity-selection mass spectrometry) is beneficial.
- Experience in outsourcing and managing external collaborations (including CROs) is advantageous.
- Prior experience in leadership and direct/indirect management roles in an early drug discovery setting is desirable.
Regular
RelocationDomestic/International
VISA SponsorshipYes
Travel Requirements10%
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