Senior Research Scientist, Georgia Cancer Center

2 days ago


Augusta, Maine, United States InsideHigherEd Full time
Job Summary

The Georgia Cancer Center at Augusta University is seeking a highly motivated Senior Research Scientist to join our research team. The successful candidate will have a deep immunology background and will play a crucial role in the design, development, optimization, and nomination of CAR-T cell candidates using various in vitro and in vivo phenotypic and functional assays.

Responsibilities
  • Independently plan, execute, analyze, and report on experiments to support the preclinical development of novel T cell therapy products.
  • Genome editing and culturing human pluripotent stem cells in various conditions.
  • Perform in vitro cell-based functional assays (cytotoxicity, cytokine, proliferation, etc.) for CAR T cell therapeutic candidate selection.
  • Design, execute, and analyze flow cytometry experiments for CAR T cell product characterization.
Requirements
  • PhD or equivalent in Cell or Molecular Biology/Biological Sciences with 10 or more years research experience.
  • Extensive hands-on experience with Molecular Biology (as PCR, qRT-PCR, ddPCR, DNA/RNA and protein preparation), Cloning, mammalian cell culture and transfection.
  • Experience with multi-color flow cytometry, panel design, and data analysis.
  • Willingness to accept responsibilities outside of initial job description.
Preferred Qualifications
  • Experience with human CAR T cell engineering.
  • Experience using viral (lentiviral, retroviral or AAV) and/or nonviral gene delivery methods (e.g., CRISPR mediated knockin or targeted genome integration).
  • Experience with immunological assays, such as cytokine/chemokine analysis (e.x. ELISA or Luminex), cytotoxicity and in vitro cell-based assays live cell analysis.
  • Proficiency in using data analysis tools such as FlowJo and GraphPad Prism.
  • Understanding of US FDA cGMP and international regulatory requirements is welcomed.


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