Research Scientist Inflammation Discovery

1 week ago

MA United States Takeda Pharmaceuticals Full time
About the Role

Takeda Pharmaceuticals is seeking a highly skilled Research Associate Scientist to join our Gastrointestinal and Inflammation (GI2) Drug Discovery Unit. As a key member of our biology and cross-functional discovery teams, you will play a critical role in delivering an industry-leading portfolio of drugs for various gastrointestinal, autoimmune, and inflammatory diseases.

Key Responsibilities
  • Develop and execute preclinical development strategies to support candidate selection, facilitating efficient clinical validation of impactful medicines for patients with inflammatory disorders.
  • Apply deep scientific and technical expertise in immunology and/or cell biology to mature innovative novel concepts within our team, in matrixed collaboration with other Takeda scientists, and external partners.
  • Drive an inclusive, open, and effective culture in a fast-growing drug discovery group.
Accountabilities
  • Generate data packages supporting candidate selection and asset characterization based on current in vitro methods, including immortalized cell lines, primary cell cultures, and multicellular or organoid culture models.
  • Champion scientific integrity and rigor in preparation and interpretation of detailed protocols/SOPs.
  • Independently plan assignments for a research work group or project, troubleshoot complex problems, and change experimental design if necessary.
  • Develop and validate new methods to support completion of complex assignments within a project.
  • Exercise independent judgment in selecting methods, coordinating efforts, evaluating criteria for obtaining results, and utilizing technical literature to implement novel procedures.
  • Interpret and analyze data, helping to incorporate results into overall scientific projects, and independently generate novel hypotheses.
  • Maintain a proactive and vocal approach to improving departmental efficiency.
  • Summarize and present literature data within the department and occasionally to a broader audience.
Requirements
  • MS in a scientific discipline with 3+ years' experience, or BS with 5+ years' experience.
  • Expertise in at least one of the following assay methods: ELISA/MSD, Western blot, qPCR, flow cytometry, ChIP.
  • Experience with cell culture, including isolation, culture, and analysis of primary immune cell subsets.
  • Direct experience with the principles, models, and pathways of autoimmunity, inflammation, and/or fibrosis.
  • Experience developing and/or evaluating small molecule, biologic, and/or nucleic acid therapeutics.
  • Demonstrates strong organizational and project management skills and effective written and verbal communication skills.
Preferred Qualifications
  • Familiarity with in vivo study design/execution.
  • Modern high-dimensional gene expression analysis (i.e., scRNAseq).
  • Multicellular culture systems (i.e., organoids).
What We Offer

Takeda Pharmaceuticals offers a competitive salary range of $96,000 to $151,800, depending on qualifications and experience. Additionally, U.S. based employees may be eligible for short-term and/or long-term incentives, medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits.

Takeda Pharmaceuticals is an equal opportunity employer and welcomes applications from diverse candidates. We are committed to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state, and local laws, and any other characteristic protected by law.

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