Director of Protein Production and Quality Attributes
4 weeks ago
Bristol Myers Squibb is a leading biopharmaceutical company dedicated to transforming patients' lives through science. We are seeking a highly skilled and experienced professional to join our team as a Director of Protein Production and Quality Attributes.
The successful candidate will be responsible for leading a team of scientists in the production and characterization of monoclonal antibodies, multi-specifics, antibody-drug conjugates (ADCs), and other protein therapeutics using state-of-the-art technology and an industry-competitive DNA-to-protein production process.
The Director will play a key role in innovating and advancing Discovery Biotherapeutics function capabilities, supporting drug development initiatives, and ensuring the success of BMS's research activities.
The ideal candidate will have a strong background in protein production, cloning, and purification, with experience in managing high-performing teams and collaborating with cross-functional teams.
Responsibilities:
- Manage, mentor, and develop a high-performing team dedicated to excellence in biologics cloning, production, and purification.
- Apply deep scientific knowledge of protein production, concepts, and methodologies to deliver on biotherapeutics pipeline.
- Manage high-throughput, medium, and large-scale production of biologics end-to-end.
- Advance cloning and purification platforms to produce and characterize monoclonal and bispecific antibodies, fusion proteins, and ADCs.
- Apply protein structural and biophysical principles to optimize the production and manufacturability of therapeutic candidates.
- Identify and implement new technologies, applications, and external collaborations to support research goals.
- Interface with technology providers to keep on par with industry leading protein cloning, production, purification, and manufacturability.
- Foster a continuous improvement mentality to drive platform development in terms of speed, quality, and robustness.
- Integrate analytical characterization data to optimize biologics production.
- Ensure clear communication among team members and across teams to foster a culture of proactive collaboration and engagement.
Basic Qualifications:
- Bachelor's Degree with 15+ years of academic/industry experience
- or
- Master's Degree with 12+ years of academic/industry experience
- or
- PhD with 8+ years of academic/industry experience with 6+ years leadership experience
Preferred Qualifications:
- Ph.D. in Biochemistry, Biotechnology, Molecular Biology, or a related field
- 10+ years of increasing responsibilities and experience in protein cloning, production, purification, and quality analyses, preferably in an industry setting.
- Demonstrated leadership and people management skills, with the ability to effectively lead and manage teams.
- Strong strategic vision and experience in developing and executing strategic plans that align with organizational goals.
- Excellent analytical and problem-solving skills, with the ability to identify challenges and propose innovative solutions.
- Exceptional communication and collaboration skills, with the ability to effectively interact with cross-functional teams and stakeholders at all levels.
- Hands-on experience with CHO and other mammalian cells for mAb or recombinant protein production is a must.
- Experience in tech transfer, including drafting reports, protocols, and knowledge for process transfer.
- Demonstrated ability to successfully and efficiently coordinate multiple work streams and projects simultaneous.
- Track record of scientific publications and presentations at meetings, or authorship of patents and regulatory documents.
Bristol Myers Squibb is an equal opportunity employer and welcomes applications from diverse candidates. We are committed to creating an inclusive work environment that values diversity, equity, and inclusion.
Join us in our mission to transform patients' lives through science.
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