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In Vitro Pharmacology Scientist I/II
2 months ago
Scribe Therapeutics is a pioneering molecular engineering firm dedicated to developing exceptional in vivo therapies aimed at addressing the root causes of diseases. Founded by leading figures in CRISPR technology, Scribe is pushing the boundaries of current genome editing methods by creating custom-engineered enzymes and innovative delivery systems as part of our proprietary CRISPR by Design™ platform for genetic medicine.
We are in search of an innovative, enthusiastic, and driven individual to contribute to our mission of advancing the next generation of CRISPR-based therapeutics. This role is for a Scientist I/II who will play a crucial part in our ongoing initiatives to engineer highly effective and precise CRISPR enzymes. The ideal candidate will have a strong interest in characterizing CRISPR systems that propel our therapeutic projects, with a focus on establishing robust workflows for in vitro pharmacological evaluations. Collaboration will be key, as this role involves working closely with interdisciplinary teams, including protein engineers, process scientists, computational biologists, next-generation sequencing experts, and specialists in various diseases.
The selected candidate will have numerous opportunities for professional advancement within a rapidly expanding biotechnology startup, including the potential to grow into a leadership position with increasing responsibilities and the chance to publish significant findings in respected peer-reviewed journals.
Key Responsibilities:
- Design, optimize, and validate cellular and protein assays.
- Conduct in vitro cellular and molecular biology assays, analyze data, and document findings.
- Effectively communicate research strategies and outcomes to team members both verbally and in writing.
- Collaborate seamlessly with team members to ensure project execution aligns with established timelines.
- Promote a dynamic, fast-paced, and enjoyable environment conducive to rigorous scientific inquiry.
Required Skills and Qualifications:
- A PhD (or equivalent experience) in Biology, Bioengineering, Cell Biology, Genetics, or a related field.
- A minimum of 2-5 years of industry experience with a proven track record in assay development and validation.
- Expertise in experimental and workflow design for in vitro pharmacology assessments.
- Ability to work both independently and collaboratively within a fast-paced, interdisciplinary research team.
- Experience with protein assays (Western blotting, ELISA, immunofluorescence), RNA-based assays (qPCR, ddPCR), molecular biology techniques, flow cytometry, and/or high-content imaging.
- Experience in screening and characterizing molecules using both cell-free and cell-based assays, including drug dose-response, mechanism of action, and cellular efficacy.
- Proficiency in culturing primary cell models.
- Familiarity with neuroscience disease models.
Preferred Skills and Qualifications:
- Experience with CRISPR-Cas gene editing systems and associated delivery technologies.
- Prior experience in pharmaceutical, biotechnology, or contract research organizations is highly desirable.
Compensation will be commensurate with experience. We offer an intellectually stimulating, collaborative, and fast-paced work environment. If you are prepared to shape the future of therapeutics, we look forward to your application.
We are committed to fostering a diverse workplace and are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.
The salary range for this position is $115,000-130,000 per year, with the final offer depending on internal equity and the candidate's relevant skills, experience, qualifications, training, and market data. Additional incentives are included as part of the comprehensive benefits package.
