Senior Scientist I, CMC BioProcess Purification Development Specialist

5 hours ago

South San Francisco, California, United States AbbVie Full time
Job Summary

We are seeking a highly skilled Senior Scientist I to join our CMC BioProcess Purification Development team at AbbVie in the Bay Area. As a key member of our team, you will be responsible for developing robust, phase-appropriate processes for drug substance GMP production to enable human clinical studies and eventual licensure.

Key Responsibilities
  • Design, optimize, and scale-up purification processes for biologics candidates to support early and late stage development
  • Transfer processes to GMP manufacturing for clinical material production
  • Work with contract labs and carry out viral clearance studies
  • Conceive and evaluate novel, advanced bioprocess technologies that are in line with the group's strategy
  • Proactively seek out new information in the literature and incorporate this into individual project(s) as well as the overall program
  • Maintain a high level of productivity in the lab
  • Write technical publications, reports, presentations, and regulatory filings
  • Work efficiently, collaboratively, and cross-functionally toward project timelines and goals
Requirements
  • Bachelor's degree in Chemical Engineering, Biochemistry, Chemistry, or other sciences, or equivalent education and experience
  • Minimum 10 years of experience in CMC protein purification with standard bioprocess unit operations such as chromatography separations and filtration
  • Ability to independently design, execute, use, and reference literature publications, and interpret laboratory experiments to answer scientific questions
  • Ability to manage and organize large data sets to help interpret results using data visualization tools
  • Strong communication skills, including verbal, written, and scientific data presentation
  • Ability to work collaboratively within and outside of the group
Preferred Qualifications
  • Proficient in writing methods and operating AKTA chromatographic instruments
  • Strong understanding of analytical techniques, such as HPLC and ELISA
  • Hands-on experience with monoclonal antibody or antibody-like molecule purification process development at laboratory, pilot, and/or GMP scale
About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio.

We are committed to operating with integrity, driving innovation, transforming lives, serving our community, and embracing diversity and inclusion.

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