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Senior Research Scientist
2 months ago
Abbott Laboratories is a global healthcare leader seeking an experienced Principal Scientist to lead cutting-edge research in enzymology. The successful candidate will oversee and conduct research to identify, characterize, optimize, and develop proteins used for nucleic acid amplification and sample preparation technologies.
Key Responsibilities- Lead protein characterization, optimization, and development efforts, from design of experiments through laboratory studies.
- Perform kinetic, thermodynamic, and structure-function studies.
- Apply computational modeling to drive protein characterization and optimization efforts.
- Initiate and oversee proteomics efforts in-house and via collaboration.
- Provide cloning, protein expression, separation, and purification expertise.
- Implement mutagenesis studies to help characterize and optimize proteins of interest.
- Drive the introduction of new, optimized, and/or modified proteins to improve product performance.
- Design and implement procedures, processes, and key performance indicators to monitor, characterize, and QC proteins.
- Provide high-level analysis of experimental results.
- Provide written reports and oral presentations to executives.
- Bachelor's Degree in Biochemistry/Biophysics/Protein chemistry, or a closely related field, and 10 years of experience in a similar area.
- Minimum ten years of full-time laboratory experience in an industrial setting.
- Hands-on expertise using kinetic, thermodynamic, and structure-function experimental approaches.
- Expertise with computational modeling of proteins and protein/nucleic acid interactions to drive characterization of protein functionality and to drive the incorporation of protein modifications to improve/alter function.
- Extensive experience characterizing DNA/RNA interacting/binding proteins.
- Expertise in optimizing protein expression and purification methods.
- Expertise in developing, optimizing, and performing in vitro enzymatic assays.
- Experience with high-throughput genetic/molecular screening a plus.
Abbott Laboratories is a global healthcare leader that helps people live more fully at all stages of life. Our portfolio of life-changing technologies spans the spectrum of healthcare, with leading businesses and products in diagnostics, medical devices, nutritionals, and branded generic medicines.
We offer a comprehensive benefits package, including career development opportunities, free medical coverage, an excellent retirement savings plan, tuition reimbursement, and a company recognized as a great place to work in dozens of countries around the world.
