Genetic Screening Research Specialist I, II, III

2 weeks ago

California, United States Amber Bio Full time

Company Overview:

Amber Bio is at the forefront of biotechnology, innovating in gene editing techniques to address previously untreatable patient populations. Established by leaders in the CRISPR domain from top-tier research institutions, the company is advancing a groundbreaking RNA writing platform capable of correcting extensive genetic mutations in a safe and reversible manner. We are expanding our team and have multiple positions available. As an early member of our team, you will play a crucial role in shaping our strategic direction and future recruitment efforts.

Position Title: Genetic Screening Research Specialist I, II, III

Key Responsibilities:

  • Conduct massively parallel reporter assays and high-throughput screening across various cellular environments utilizing both cellular and molecular readouts.
  • Design and implement molecular biology protocols including vector construction, DNA/RNA extraction, RT-PCR, qPCR, and next-generation sequencing (Illumina and Nanopore).
  • Independently and collaboratively troubleshoot experiments to enhance screening efficiency, sensitivity, and accuracy.
  • Assist in cell culture operations and experiments across multiple cell lines, both at small and large scales.
  • Develop and perform cell-based assays (AAV/lentiviral transduction, transfection, flow cytometry, immunostaining, and other plate reader assays).
  • Engineer and evaluate cell-based reporter systems utilizing synthetic biology methodologies.
  • Proactively identify and resolve technical challenges, suggesting corrective measures based on observations and literature reviews.
  • Compile data summaries and present findings to colleagues and management.
  • Create standard operating procedures, adhere to protocols, meticulously document experimental results in lab notebooks, and maintain organized electronic records.
  • Prepare scientific reports and data summaries.
  • Collaborate with interdisciplinary teams to achieve project objectives, linking early discovery efforts with high-throughput screening to identify and refine candidates for further analysis.

Qualifications:

  • Bachelor's or Master's degree in Biology, Biochemistry, Chemical Engineering, Biological Engineering, or a related discipline.
  • A minimum of 1 year of laboratory experience.
  • Experience in mammalian cell culture (culturing, transfecting, and transducing cells, as well as DNA/RNA purification).
  • Proficiency in molecular biology techniques (vector design and cloning, qPCR, primer and probe design, DNA/RNA extraction workflows).
  • A critical thinker with strong communication skills, thriving in a multidisciplinary and fast-paced team environment.
  • Excellent written and verbal communication abilities.

Preferred Attributes:

  • High motivation, strong work ethic, and a commitment to making a significant impact.
  • Attention to detail with the capability to derive deep insights from data.
  • Ability to think critically and refine intuition based on new data.
  • Capacity to independently transition from ideation to data generation.
  • A long-term vision for personal development with clear career objectives.
  • Strong emotional intelligence and a collaborative mindset.
  • Experience with pooled, high-throughput screening utilizing next-generation sequencing readouts, and/or preparing screening plasmid libraries from synthesized oligo arrays.
  • Familiarity with CRISPR-Cas systems and/or gene editing and delivery technologies.
  • Experience in preparing next-generation sequencing libraries (Illumina and/or Nanopore platforms).

If you are passionate about advancing gene editing technologies and wish to contribute to a pioneering biotechnology company, we invite you to consider joining our dynamic team.

Amber Bio is an equal-opportunity employer and encourages applications from candidates of diverse backgrounds. We value diversity and are committed to fostering an inclusive and supportive work environment for all employees.

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