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In Vitro Pharmacology Scientist I/II
2 months ago
Scribe Therapeutics is a pioneering molecular engineering firm dedicated to developing leading-edge in vivo therapies aimed at addressing the root causes of diseases. Founded by renowned CRISPR innovators and molecular engineering experts, Scribe is pushing the boundaries of existing genome editing technologies through the creation of custom-engineered enzymes and innovative delivery systems as part of our proprietary CRISPR by Design™ platform for genetic medicine.
We are in search of a highly innovative, enthusiastic, and driven individual to contribute to our mission of creating the next generation of CRISPR-based therapeutics. This role is designated for a Scientist I/II to enhance our ongoing initiatives in engineering highly effective and precise CRISPR enzymes. The ideal candidate should possess a strong interest in characterizing CRISPR systems that propel our therapeutic projects, with a focus on establishing robust workflows for in vitro pharmacological assessments. Collaboration across interdisciplinary teams, including protein engineers, process scientists, computational biologists, next-generation sequencing specialists, and disease experts, will be essential.
The selected candidate will encounter numerous opportunities for professional advancement within a rapidly expanding biotechnology startup, including the potential to assume leadership roles with increasing responsibilities and the chance to publish significant findings in reputable scientific journals.
Key Responsibilities:
- Design, refine, and validate cellular and protein assays.
- Conduct in vitro cellular and molecular biology experiments, analyze data, and document findings.
- Effectively communicate research strategies and outcomes to team members both verbally and in written form.
- Collaborate efficiently with team members to ensure project execution within set timelines.
- Promote a dynamic, fast-paced, and enjoyable environment conducive to rigorous scientific inquiry.
Required Skills and Qualifications:
- A PhD (or equivalent experience) in Biology, Bioengineering, Cell Biology, Genetics, or a related field.
- 2-5 years of industry experience with a proven history in assay development and validation.
- Expertise in experimental and workflow design for in vitro pharmacological evaluation.
- Ability to work autonomously and collaboratively within a fast-paced, interdisciplinary research environment.
- Experience with protein assays (Western blotting, ELISA, immunofluorescence), RNA-based assays (qPCR, ddPCR), molecular biology techniques, flow cytometry, and/or high-content imaging.
- Familiarity with screening and characterization of compounds using both cell-free and cell-based assays, including drug dose-response and cellular efficacy studies.
- Experience in culturing primary cell models.
- Knowledge of neuroscience disease models.
Preferred Skills and Qualifications:
- Experience with CRISPR-Cas gene editing technologies and delivery methods.
- Prior experience in pharmaceutical, biotechnology, or contract research organizations is highly desirable.
Salary will be commensurate with experience. We offer an intellectually stimulating, collaborative, and fast-paced work environment. If you are ready to shape the future of therapeutics, we look forward to your application.
We are committed to fostering a diverse workplace and are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.
At the time of posting, the base pay wage range for this role is $115,000-130,000 per year. The offered pay range will depend on internal equity and the candidate's relevant skills, experience, qualifications, training, and market data. Additional incentives are provided as part of the complete package in addition to comprehensive medical and other benefits.
