Technical Lead in Molecular Diagnostics

22 hours ago


Palo Alto, California, United States Guardant Health Full time

Company Overview
Guardant Health is a pioneering precision oncology company committed to revolutionizing cancer care. With our cutting-edge technology and data-driven approach, we are transforming the way cancer is diagnosed, treated, and managed. Our team is comprised of talented individuals who share a passion for innovation and a dedication to improving patient outcomes.

The Role
We are seeking an exceptional technical leader in bioinformatics and molecular diagnostics to join our team. As a senior staff member, you will be responsible for driving pivotal initiatives, nurturing the next generation of scientific talent, and establishing standards that inspire and guide your colleagues. Your expertise in software development, regulatory compliance, molecular biology, and quality systems will enable you to make a meaningful impact on our business outcomes.

Key Responsibilities
Partner with Technology Development to design and validate experimental protocols, from initial R&D through regulatory submission
Architect and enhance bioinformatics algorithms powering new diagnostic development and existing production workflows
Lead technical initiatives hands-on while mentoring teams in building robust, scalable bioinformatics pipelines
Develop data management strategies optimizing product performance and empowering cross-team collaboration
Evaluate cost-benefit analyses for performance improvements and COGS reduction
Stay current with cutting-edge sequencing technologies and computational methods
Build consensus across scientific, quality, regulatory, and business teams to align priorities with user needs
Guide complex projects from conception to completion, anticipating challenges and ensuring timely delivery

Requirements
PhD level with 10+ years related industry experience
Expert experience with data and statistical analysis using Python
Expert developing bioinformatics pipelines in one or more languages (e.g., Python, R, Java, C++, Rust)
Comfortable developing in cloud environments and using workflow managers
5+ years managing and troubleshooting genetic sequencing assays or tests
Statistical design for experiments for development and validation of diagnostics in a regulated environment (e.g., CAP/CLIA, FDA)
Ability to design well-tested software that interfaces in larger systems and is extensible by other team members and teams
Proven mentor and leader of teams that have successfully developed and launched medical diagnostics

About the Opportunity
This role offers a challenging and rewarding career path, with opportunities to shape the future of precision oncology. We offer a competitive salary range of $173,600 - $234,300, depending on location and experience, as well as a hybrid work model that balances in-person collaboration and focused individual time. If you are a motivated and experienced bioinformatics scientist looking to take on a leadership role, we encourage you to apply.



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