Senior Bioinformatics Expert

2 days ago


Palo Alto, California, United States Guardant Health Full time

About the Company
Guardant Health is a leading precision oncology company dedicated to conquering cancer globally. Our proprietary tests, vast data sets, and advanced analytics drive commercial adoption, improve patient clinical outcomes, and lower healthcare costs across the cancer care continuum. We have commercially launched several cutting-edge tests for advanced-stage cancer patients, including Guardant360, Guardant360 CDx, Guardant360 TissueNext, Guardant360 Response, and GuardantOMNI. For early-stage cancer patients, we offer the Guardant Reveal test. Our screening portfolio, featuring the Shield test, aims to address the needs of individuals eligible for cancer screening.

The Role
You will be a technical leader in bioinformatics and molecular diagnostics, driving pivotal initiatives and nurturing the next generation of scientific talent. As a trusted advisor, you will pinpoint strategic opportunities that enhance team capabilities and business outcomes, establishing standards that inspire and guide your colleagues. Leveraging your extensive expertise in software development, regulatory compliance, molecular biology, and quality systems, you will partner with Technology Development to design and validate experimental protocols, from initial R&D through regulatory submission.

Key Responsibilities
Design and validate experimental protocols in collaboration with Technology Development
Architect and enhance bioinformatics algorithms powering new diagnostic development and existing production workflows
Lead technical initiatives hands-on while mentoring teams in building robust, scalable bioinformatics pipelines
Develop data management strategies optimizing product performance and empowering cross-team collaboration
Evaluate cost-benefit analyses for performance improvements and COGS reduction
Stay current with cutting-edge sequencing technologies and computational methods
Build consensus across scientific, quality, regulatory, and business teams to align priorities with user needs
Guide complex projects from conception to completion, anticipating challenges and ensuring timely delivery
Synthesize and communicate findings effectively, from internal presentations to regulatory submissions and peer-reviewed publications

Requirements
PhD level with 10+ years related industry experience
Expert experience with data and statistical analysis using Python
Expert developing bioinformatics pipelines in one or more languages (e.g., Python, R, Java, C++, Rust)
Comfortable developing in cloud environments and using workflow managers
5+ years managing and troubleshooting genetic sequencing assays or tests
Statistical design for experiments for development and validation of diagnostics in a regulated environment (e.g., CAP/CLIA, FDA)
Ability to design well-tested software that interfaces in larger systems and is extensible by other team members and teams
Proven mentor and leader of teams that have successfully developed and launched medical diagnostics

About the Opportunity
This role offers a unique blend of technical leadership, innovation, and collaboration. You will have the opportunity to shape the direction and strategy for the development of new diagnostics and the expansion of production capabilities at Guardant. In return, we offer a competitive salary range of $173,600 - $234,300, depending on location and experience, as well as a hybrid work model that balances in-person collaboration and focused individual time. If you are a motivated and experienced bioinformatics scientist looking to take on a leadership role, we encourage you to apply.



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