Senior Research Associate, Structural Biology

1 week ago


Fremont, California, United States Bayside Solutions Full time
Senior Research Associate, Structural Biology

We are seeking a highly skilled Senior Research Associate to join our Structural Biology team. As a key member of our team, you will be responsible for generating protein crystal structures to support multiple oncology therapeutic programs.

Key Responsibilities:

  • Apply expertise in protein purification, identification, and optimization of crystallization conditions.
  • Generate protein crystal structures using X-ray crystallography techniques.
  • Collaborate with cross-functional teams to design and execute experiments.
  • Document research progress and maintain accurate records.

Requirements:

  • MSc in biology, biochemistry, enzymology, or a related field with 2 years of experience; alternatively, BSc. with 4-5 years of experience.
  • Experience with protein handling, characterization, and storage (FPLC or HPLC techniques like SEC and affinity chromatography. PAGE, quantitation via Bradford and nanodrop, etc.).
  • Experience with protein-protein complexes, including antibodies/Fabs, molecular glues, and PROTACs.
  • Able to follow written protocols and document research progress.
  • Rigorous, quantitative, detail-oriented experimentalist
  • Excellent written and verbal communication skills
  • Conscientious team player interested in a fast-paced biotech environment.
  • Willingness to learn and improve processes

Preferred Qualifications:

  • Experience with growing and harvesting protein crystals is highly desired. Prior use of crystallographic software suites (CCP4, Phenix) and visualization software (PyMOL, Chimera) is also preferred.
  • Experience with biophysical characterization such as MS, Thermal Shift Analysis, and SPR is a plus.
  • Experience with protein-ligand crystallization and refinement
  • Experience in protein expression, including construct design and protein engineering.

Bayside Solutions, Inc. is an equal opportunity employer and welcomes applications from diverse candidates.


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