PK/PD and QSP Modeler, Neuroscience – Senior Scientist, DMPK

2 weeks ago


Boston, Massachusetts, United States Takeda Pharmaceutical Full time
About the Role

Takeda is a forward-thinking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients worldwide. We are seeking a highly skilled PK/PD and QSP modeler to join our team in Cambridge, MA.

Key Responsibilities
  • Develop a quantitative model of novel therapeutic agents to treat various neurological diseases, including neurodegeneration and neuromuscular diseases.
  • Collaborate with cross-functional teams to develop a quantitative model-based understanding of the interactions of target biological pathways and novel therapeutic agents, and their impact on disease progression.
  • Formulate and implement a team-engaged modeling and simulation strategy.
  • Design and build translational PK/PD/efficacy and mechanistic and/or systems models to assist and accelerate decisions around drug candidate selection, study design optimization, and biomarker selection.
  • Enable translational predictions of human pharmacologically active/efficacious dose, dosing schedule, and safety margin for clinical trials.
Requirements
  • MS/PhD/PharmD in chemical or biomedical engineering, pharmaceutical sciences, mathematics, physics, or equivalent area.
  • Strong competency in building mathematical models in commonly used languages such as MATLAB, SimBiology, NONMEM, Phoenix, Python, or R.
  • At least 2 years (8 years with MS) of industry experience in mathematical modeling of biological systems.
  • Demonstrated strong analytical skills to evaluate complex information and identify key scientific questions.
  • Ability to communicate complex modeling results clearly and concisely to cross-functional audiences.
What We Offer

Takeda offers a competitive salary range of $133,000.00 to $209,000.00, depending on qualifications and experience. We also offer a comprehensive benefits package, including medical, dental, vision insurance, a 401(k) plan, and company match, short-term and long-term disability coverage, basic life insurance, tuition reimbursement, paid volunteer time off, company holidays, and well-being benefits.

Takeda is an equal opportunity employer and welcomes applications from diverse candidates. We are committed to creating a diverse and inclusive workplace and are proud to be an EEO employer.



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