Senior Scientist, Biochemistry and Biophysics

3 days ago


Oklahoma City, Oklahoma, United States Treelinebiosciences Full time
About Treeline Biosciences

Treeline Biosciences is a pioneering biotechnology company dedicated to developing innovative medicines against challenging targets in cancer and other life-threatening diseases. Our team of experienced scientists and executives is committed to applying cutting-edge tools in genomics, lead discovery, medicinal chemistry, and computation to accelerate drug discovery.

The Role

We are seeking an experienced Biochemist & Biophysicist to join our team in Watertown, Massachusetts. The successful candidate will play a critical role in supporting our drug discovery programs by collaborating with our multi-disciplinary Lead Discovery organization and contributing to the development of new biophysical assays to characterize protein-small molecule and protein-protein interactions.

Responsibilities
  • Design and implement biophysical assays to analyze compound interactions in support of hit ID, hit to lead, and lead optimization activities.
  • Utilize a range of biophysical techniques, including SPR, DSF, MS, DLS, and MST, to advance drug discovery.
  • Analyze and interpret biophysical data to inform program decisions.
  • Collaborate with cross-functional project teams to propose and evaluate new approaches and technologies.
  • Provide biophysics leadership to project teams.
Requirements
  • PhD in Biophysics, Biochemistry, Chemistry, Chemical Biology, or related discipline with 2-3 years of postdoctoral training.
  • 5+ years of experience in biotech/pharma industry with a track record of hit-finding, hit-to-lead, and lead optimization.
  • Strong knowledge of biophysical methods and theory with hands-on expertise applying biophysics for interaction analysis.
  • Experience with SPR, MST, DSF, MS, or NMR is a plus.


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