Senior Scientist, Immuno-Oncology Research

1 day ago


Philadelphia, Pennsylvania, United States Legend Biotech US Full time
Job Title: Principal Scientist, I/O Discovery

Legend Biotech US is seeking a highly skilled Principal Scientist to join our Exploratory Technology team in Philadelphia, PA. As a key member of our interdisciplinary team, you will play a crucial role in developing our company's cell therapy platform for solid tumor applications.

Key Responsibilities:
  • Design and execute CAR-T cell functional assays to advance our cell therapy platform.
  • Conduct in vivo studies with human and murine tumor models to evaluate the efficacy of our cell therapies.
  • Develop novel armor strategies to enhance the performance of our cell therapies.
  • Analyze and interpret data, troubleshoot, and present findings to internal stakeholders and cross-functional teams.
  • Stay up-to-date with the latest advancements in cell therapy for solid tumors and demonstrate deep insight into selected disease areas.
Requirements:
  • PhD degree in biological sciences (Immunology, Immuno-Oncology, Cancer Biology) or related field.
  • Senior Scientist- PhD + 3 years of industry experience.
  • Principal Scientist- PhD, 5 years of postgraduate experience with a minimum of 4 years of industry experience.
  • Previous work experience in target discovery, validation, and IND filing in Cell Therapy space is strongly preferred.
  • Relevance experience of utilizing T cell biology is required. Additional experience of using NK cell, T cell is strongly preferred.
  • Proficiency in conventional immunological techniques such as primary T cell isolation, gene editing/transduction, expansion, ELISA, cell sorting, and flow cytometry is required.
  • Experience in CAR-T animal models, in vivo study design, and execution is required.
  • In-depth knowledge in topics such as human tumor microenvironment (TME), tumor-infiltrating-lymphocytes (TIL), tertiary lymphoid structures (TLS), Immune Checkpoint Blockade (ICB) is preferred. Hands-on experience with translational biomarker studies is preferred.
  • Innovation in cell therapy space is preferred as evidenced by publications and patents.
  • Language: English.

Legend Biotech US is an equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. We maintain a drug-free workplace.



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