Principal Scientist, Clinical Pharmacologist/Modeling and Simulation Expert
2 days ago
Lycia Therapeutics is a biotechnology company pioneering the development of novel therapeutics that degrade extracellular and membrane-bound proteins. Leveraging its lysosomal targeting chimera (LYTAC) platform, the company is advancing a pipeline of first-in-class therapeutics with the potential to address key unmet medical needs.
The RoleWe are seeking a highly motivated and organized Principal Scientist with a strong background in pharmacokinetics to join our team. As a Pharmacokinetics/Clinical Pharmacology Principal Scientist, you will play a key role in developing novel small molecule and protein-based therapeutics. Your expertise will be instrumental in shaping the development trajectory of our innovative therapeutic candidates and bringing transformative therapies to patients in need.
Key Responsibilities- Perform pharmacokinetic data analysis, including non-compartmental and compartmental analyses, to derive relevant pharmacokinetic parameters.
- Drive the application of quantitative pharmacokinetic-pharmacodynamic (PK-PD) modeling to guide LYTAC dose selection, dose regimen optimization, and exposure-response relationships in non-clinical studies.
- Author regulatory submissions and serve as a pharmacokinetics/clinical pharmacology subject matter expert during interactions with regulatory agencies.
- Collaborate closely with research and development teams to define project objectives and design innovative and scientifically rigorous pharmacokinetic studies.
- PhD in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, or related field with at least 7-8 years of pharmacokinetics or PK/PD modeling experience within a pharmaceutical, biotechnology, or research setting.
- Proven track record of designing, executing, and analyzing pharmacokinetic studies, integrating pharmacology and pharmacokinetics data to generate quantitative models.
- Strong proficiency in pharmacokinetic software (e.g., WinNonlin, NONMEM) and relevant modeling tools.
- Ability to adhere to tight timelines across multiple research projects and adapt to changing priorities.
Lycia offers a competitive employment package that includes an annual bonus, equity, and a generous benefits package. We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
-
Principal Scientist Pharmacometrics Expert
2 weeks ago
San Diego, California, United States Affinity Executive Search Full timeJob Title: Principal Scientist PharmacometricsWe are seeking a highly skilled Principal Scientist to join our dynamic Pharmacometrics team at a Top Tier BioPharmaceutical company.About the Role:The Pharmacometrics Group applies a range of model-informed drug development (MIDD) approaches to support early and late-stage development of small and large...
-
Principal Modeling and Simulation Engineer
3 weeks ago
San Francisco, California, United States Raytheon Full timeAbout the RoleAt Raytheon, we are seeking a highly skilled Principal Modeling and Simulation Engineer to join our team. As a key member of our Integrated Solutions Modeling and Architecture (ISMA) directorate, you will be responsible for developing and integrating mission simulations, virtual prototypes, and system emulators that represent a variety of...
-
South San Francisco, California, United States Biogen Full timeJob Title: Principal Clinical Scientist, Rare Autoimmune DiseasesBiogen is seeking a highly experienced Principal Clinical Scientist to join our West Coast hub, focusing on transforming the lives of patients with severe immune-mediated diseases. As a key member of our clinical research team, you will play a crucial role in supporting clinical research...
-
Network Modeling and Simulation Expert
3 weeks ago
San Diego, California, United States MITRE Full timeJob Title: Network Modeling and Simulation ExpertMITRE is seeking a highly skilled Network Modeling and Simulation Expert to join our team. As a Network Modeling and Simulation Expert, you will be responsible for designing, developing, and implementing network models and simulations to support our nation's most complex problems.Key Responsibilities:Design...
-
Network Modeling and Simulation Expert
2 weeks ago
San Diego, California, United States MITRE Full timeJob Title: Network Modeling and Simulation ExpertMITRE is seeking a highly skilled Network Modeling and Simulation Expert to join our team. As a Network Modeling and Simulation Expert, you will be responsible for designing, developing, and implementing network models and simulations to support our customers' needs.Key Responsibilities:Design and develop...
-
South San Francisco, California, United States Lycia Therapeutics Full timeAbout the RoleLycia Therapeutics, a pioneering biotechnology company, is seeking a highly skilled Principal Scientist to join our team. As a key member of our research and development team, you will play a crucial role in advancing our innovative therapeutic candidates.Key ResponsibilitiesPerform pharmacokinetic data analysis, including non-compartmental and...
-
Principal Scientist in Cheminformatics
2 weeks ago
San Francisco, California, United States Harnham Full timeJob Title: Principal Scientist in CheminformaticsWe are seeking a highly skilled and motivated Principal Scientist in Cheminformatics to join our dynamic research team.Key Responsibilities:Develop and implement innovative cheminformatics approaches to support drug discovery projects from target identification through lead optimization.Utilize computational...
-
Senior Scientist, PK/PD Modeling Expert
1 week ago
South San Francisco, California, United States AbbVie Full timeJob Opportunity at AbbVieAbbVie is a global organization with a mission to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We are seeking a highly skilled Senior Scientist to join our Quantitative, Translational and ADME Sciences (QTAS) group.Key...
-
Principal Clinical Research Scientist
4 weeks ago
South San Francisco, California, United States Biogen Full timeJob DescriptionJob Title: Principal Clinical ScientistJob Summary:We are seeking a highly experienced Principal Clinical Scientist to join our team at Biogen. As a key member of our clinical development team, you will be responsible for leading the design, execution, and monitoring of clinical studies evaluating novel therapies across target indications.Key...
-
South San Francisco, California, United States Lycia Therapeutics Full timeAbout the RoleLycia Therapeutics, a pioneering biotechnology company, is seeking a highly skilled Principal Scientist to join its team. As a key member of our research and development team, you will play a crucial role in advancing our innovative therapeutic candidates.Key ResponsibilitiesPerform pharmacokinetic data analysis, including non-compartmental and...
-
Network Modeling and Simulation Expert
2 weeks ago
San Diego, California, United States MITRE Full timeJob Title: Network Modeling and Simulation ExpertMITRE is seeking a highly skilled Network Modeling and Simulation Expert to join our team. As a key member of our Communications Network Engineering and Analysis Department, you will be responsible for designing, analyzing, and testing complex communication networks to solve our nation's most pressing...
-
San Francisco, California, United States Biogen, Inc. Full timeJob Title: Principal Clinical Scientist, Rare AutoimmuneBiogen, Inc. is seeking a highly skilled Principal Clinical Scientist to join our team in the development of novel therapies for rare autoimmune diseases. As a key member of our clinical research team, you will be responsible for leading the design, execution, and monitoring of clinical studies...
-
Network Modeling and Simulation Expert
3 weeks ago
San Diego, California, United States MITRE Full timeAbout the RoleWe are seeking a highly skilled Network Modeling and Simulation Expert to join our team at MITRE. As a key member of our Communications Network Engineering and Analysis Department, you will play a critical role in providing premier communications network engineering services to our customers.Key ResponsibilitiesConduct research and analysis to...
-
San Diego, California, United States Johnson & Johnson Full timeJob Title: Principal Scientist, Model-Based Meta-AnalysisJohnson & Johnson is seeking a highly skilled Principal Scientist, Model-Based Meta-Analysis (MBMA) to join our team. This role will be based in San Diego, CA; Titusville, NJ; Raritan, NJ; or Spring House, PA, with additional locations in the United States also considered.About the Role:We are looking...
-
Senior/Principal Research Scientist
3 weeks ago
San Francisco, California, United States Sofar Ocean Full timeAbout the RoleWe are seeking an exceptional Senior/Principal Research Scientist to join our Ocean Science team at Sofar Ocean. As a key member of our team, you will play a crucial role in shaping our vision for the future of ocean understanding and predictability.As a Senior/Principal Research Scientist, you will be responsible for leading our emergent AI/ML...
-
Principal Clinical Research Scientist
4 weeks ago
San Francisco, California, United States Biogen Full timeAbout the RoleWe are seeking a highly experienced Principal Clinical Research Scientist to join our team at Biogen. As a key member of our clinical research team, you will play a critical role in the design, execution, and monitoring of clinical studies evaluating novel therapies across target indications.Key ResponsibilitiesSupport the preparation of...
-
DMPK Principal Scientist
2 weeks ago
San Diego, California, United States Genesis Therapeutics Full timeAbout the RoleWe are seeking a highly skilled DMPK Principal Scientist to join our team at Genesis Therapeutics. As a key member of our drug discovery and development team, you will be responsible for driving the overall PKPD modeling and simulation effort to support projects from early research through early clinical development.Key...
-
Senior Modeling and Simulation Engineer
3 weeks ago
San Francisco, California, United States Raytheon Full timeAbout the RoleWe are seeking a highly skilled Senior Modeling and Simulation Engineer to join our team at Raytheon. As a key member of our Integrated Solutions Modeling and Architecture (ISMA) directorate, you will be responsible for developing and integrating mission simulations, virtual prototypes, and system emulators that represent a variety of mission...
-
South San Francisco, California, United States Biogen Full timeJob SummaryWe are seeking a highly skilled Principal Clinical Scientist to join our team at Biogen, a global leader in the development of innovative therapies for severe immune-mediated diseases. As a key member of our clinical development team, you will play a critical role in the design, execution, and monitoring of clinical studies evaluating novel...
-
Research Scientist, Sensor Simulation
3 weeks ago
San Francisco, California, United States Waabi Full timeTransforming the Future of TransportationWaabi is a pioneering AI company revolutionizing the self-driving industry. As a Research Engineer in Sensor Simulation, you will play a crucial role in developing cutting-edge software for autonomous driving.Key Responsibilities:Collaborate with world-renowned scientists and engineers to build innovative rendering...
