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Lead Scientist in Oncology Research

2 months ago

San Diego, California, United States RayzeBio Full time

Job Title: Principal Scientist, Biology

Location: San Diego

ID: R7

Company Overview

RayzeBio is an innovative biotechnology firm based in San Diego, CA. Established in late 2020 and recently integrated into Bristol Myers Squibb (BMS) as a wholly owned subsidiary, the organization is dedicated to enhancing the survival rates of cancer patients by leveraging targeted radioisotope technology. Operating independently within the BMS framework, RayzeBio preserves its biotech culture while benefiting from BMS's premier oncology capabilities. The company is focused on developing groundbreaking therapies targeting solid tumors, with its leading asset, RYZ101, currently in Phase 3 trials for gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and undergoing earlier stage evaluations for small cell lung cancer (SCLC). With a seasoned entrepreneurial team at the helm, RayzeBio aspires to become a global frontrunner in the field of radiopharmaceuticals.

Position Overview

This role presents a unique opportunity to spearhead the biology strategy for pipeline projects, guiding them from target selection to candidate nomination. The ideal candidate will possess extensive experience in biology, complemented by exceptional interpersonal and communication abilities. Collaboration with the leadership team will be essential to develop and implement project strategies, including resource forecasting and ensuring timely deliverables. The position demands effective teamwork within interdisciplinary settings and entails supervising junior team members while providing technical guidance in laboratory settings, particularly in the development, validation, and execution of in vitro assays and oncology models tailored to project requirements. A willingness to work with radioactive isotopes is also a prerequisite.

Key Responsibilities

Primary duties and responsibilities include, but are not limited to:

  • Leverage in-depth knowledge of cancer biology and oncology drug development to lead target selection and initiate new radiopharmaceutical projects.
  • Collaborate with cross-functional team leaders to provide strategic and operational guidance for project teams focused on specific targets.
  • Work closely with interdisciplinary teams to offer functional biology leadership throughout the lead identification and optimization phases.
  • Assist in generating preclinical GLP/non-GLP data packages to support regulatory submissions and clinical development.
  • Contribute to the formulation of a translational biology plan that aligns with the clinical development strategy.
  • Author and review study reports, regulatory documentation, scientific presentations, and publications while managing external research collaborations.
  • Evaluate scientific and research needs for projects and engage with external partners and key opinion leaders to establish necessary collaborations.
  • Act as the scientific lead for external partnerships and collaborations, guiding scientific projects through outsourcing when required.
  • Foster innovation and novel methodologies in radiopharmaceutical research and development, enhancing the company's competitive position in the industry.
  • Effectively manage internal and external resources and budgets to support corporate objectives.

Qualifications

  • PhD in cancer biology, cell biology, pharmacology, or a related discipline, with a profound understanding of cancer biology and experience in oncology drug development.
  • A minimum of 7 years of experience in pharmaceutical or biotech R&D environments, demonstrating a track record of successful accomplishments and progressive leadership roles.
  • Experience with targeted cancer therapy modalities such as radiopharmaceuticals, antibody-drug conjugates, and peptide-drug conjugates is highly desirable.

Skills

  • Exceptional written and verbal communication skills, with the ability to thrive in a fast-paced, dynamic, and collaborative environment.
  • Strong interpersonal and organizational skills, with a proven ability to motivate and enhance productivity in small company settings. Prior experience as a project leader or functional leader on interdisciplinary teams is essential.
  • Expertise in in vitro and cell-based assay development and optimization, along with proficiency in cell culture, molecular biology techniques, ELISA, flow cytometry, western blotting, qPCR, single-cell cloning, immunohistochemistry, and related protocols.
  • Familiarity with ADME/PK concepts and the drug development process, as well as experience interfacing with regulatory teams, is advantageous.
  • Experience in developing and utilizing in vivo oncology models is critical, along with the ability to design and supervise controlled in vivo experiments.
  • Capability to effectively collaborate with clinical, regulatory, CMC, and chemistry/DMPK teams, successfully leading interdisciplinary scientific teams and mentoring junior scientists.
  • Ability to work with radioisotopes while adhering strictly to radiation safety protocols.
  • Proficiency in establishing and managing external collaborations, including partnerships with CROs and academic or industrial entities.

Compensation and Benefits

The starting compensation for this position ranges from $181,021 to $212,965, in addition to incentive cash and stock opportunities based on eligibility. Compensation is determined by various factors, including required skills and job performance.

Benefit offerings are subject to the terms and conditions of applicable plans and may include medical, pharmacy, dental, and vision care, employee assistance programs (EAP), and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, and supplemental health insurance are also available. Work-life balance programs include paid national holidays, optional holidays, Global Shutdown days between Christmas and New Year's, up to 120 hours of paid vacation, and sick leave. Additional benefits include parental, caregiver, bereavement, and military leave, as well as perks like tuition reimbursement.