Lead Applications Scientist

2 weeks ago

San Diego, California, United States Singular Full time
ABOUT SINGULAR GENOMICS

Singular Genomics is at the cutting edge of genomics, one of the fastest-growing sectors globally. Our G4 Sequencing Platform is a state-of-the-art, highly adaptable benchtop genomic sequencer engineered to deliver rapid and precise outcomes. Furthermore, we are in the process of advancing the G4XTM Spatial Sequencer, an enhancement to the G4, which will utilize Singular's proprietary sequencing technology for in situ readouts in transcriptomics, proteomics, and fluorescent H&E in tissue, providing spatial context. Singular Genomics' mission is to empower researchers and healthcare professionals to propel science and medicine forward.

We cultivate a culture of innovation and technical excellence, both of which are essential for fostering creativity. We value diversity, promote teamwork, and as we continue to grow, we are always exploring ways to enhance our workplace for our employees.

Our Headquarters are situated in a prominent biotech hub. This position reports to our HQ location.

POSITION SUMMARY:

We are seeking a highly driven, detail-oriented Senior Scientist with a proven history of innovative problem-solving and achieving results. This position will be part of the R&D Spatial Research Applications Team, and the ideal candidate will focus on developing and refining in situ molecular biology assays within a collaborative environment, engaging in both practical research and client-facing activities. This role necessitates extensive expertise in molecular biology assay development, tissue processing, and preferred experience with spatial biology assays/technologies and advanced imaging techniques. You will collaborate closely with multidisciplinary teams and contribute to the advancement of our intellectual property and market-ready solutions.

RESPONSIBILITIES:
  • Experimental Planning, Execution, and Analysis: Design and conduct experiments to develop and optimize methodologies for mounting tissue samples, in situ molecular assays, and validating robustness.
  • Communication and Presentation: Collaborate effectively with teams in chemistry, engineering, materials science, image analysis, and bioinformatics. Clearly convey results across various levels of the organization through concise, cohesive, and compelling presentations.
  • Customer Engagement: Work on client service projects by designing optimal assays and ensuring that data aligns with project objectives. Deliver timely and accurate results to meet client expectations and project timelines.
  • Literature and IP Advancement: Stay updated on relevant literature and contribute to the development of intellectual property.
QUALIFICATIONS:
  • Educational Background: Ph.D. in Biology, Genetics, Bioengineering, Chemistry, Chemical Engineering, or a related field with a minimum of 4-8 years of industry or postdoctoral experience.
  • Demonstrated Commitment: A strong commitment to high-quality scientific research, evidenced by a track record of significant scientific contributions.
  • Communication Skills: Strong communication abilities, with the capacity to articulate complex results clearly across interdisciplinary teams.
  • Adaptability: Ability to thrive in a fast-paced environment, with exceptional customer service, communication, and interpersonal skills.
TECHNICAL EXPERTISE:
  • Proficient in molecular biology techniques (including method and reagent development), encompassing NGS, nucleic acid analysis, and amplification methods.
  • Expertise in fluorescence microscopy, Fluorescence In-Situ Hybridization (FISH), and handling tissue sections.
  • In-depth knowledge of spatial biology technologies and market landscape.
SPECIALIZED KNOWLEDGE:
  • Comprehensive understanding of spatial transcriptomics, including assay development and data analysis.
  • Advanced skills in multiplexed protein imaging and tissue pathology.
  • Strong bioinformatic analysis skills commonly used in spatial biology with the ability to analyze data using a wide range of tools.
  • Experience in immuno-oncology and tumor microenvironment research is highly desirable.

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