Director of Pharmacokinetics and Drug Metabolism

6 days ago


California, United States BioPhase Full time
Job Title: Director of DMPK

At BioPhase, we are seeking a highly skilled and experienced Director of DMPK to lead our drug metabolism and pharmacokinetics efforts. As a key member of our team, you will be responsible for overseeing DMPK studies to support our drug development programs, both preclinical and clinical.

Key Responsibilities:
  • Lead cross-functional project teams to design and execute PK, PK-PD, and drug metabolism studies
  • Collaborate with medicinal chemistry teams to optimize drug profiles
  • Integrate ADME, PK, and PK/PD data with biological findings
  • Manage in vivo and in vitro ADME/PK studies
  • Conduct modeling of PK and PK/PD, and predict human pharmacokinetics
  • Analyze DMPK data and develop studies to address project needs
  • Summarize and present findings to stakeholders and teams
  • Contribute to regulatory documents supporting drug development
  • Author nonclinical PK/ADME documents for submissions
Requirements:
  • PhD in a relevant scientific field, such as Biochemistry or Pharmaceutical Sciences, with at least 10 years of industry experience
  • Strong expertise in pharmacokinetics, drug metabolism, modeling, enzyme kinetics, and bioanalytical techniques
  • Experience designing and executing PK and PK-PD studies
  • Familiarity with preparing nonclinical PK/ADME documents for regulatory submissions
  • Proficient in software like Phoenix WinNonlin, Excel, and Prism; knowledge of PBPK modeling is a plus
What We Offer:
  • A dynamic and collaborative work environment
  • Opportunities for professional growth and development
  • A competitive salary and benefits package

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