Director of Computational Chemistry

1 week ago


California, United States Scienta Full time
Job Title: Director of Computational Chemistry

Location: San Diego, CA

Company: Scienta

About:

Scienta is a cutting-edge biotech startup dedicated to advancing breakthrough treatments for cancers with critical unmet medical needs. Our platform integrates covalent ligand discovery with advanced chemical biology to target previously undruggable proteins.

Position:

As the Director of Computational Chemistry, you will lead the design and application of computational methods to drive oncology drug discovery. You will collaborate closely with cross-functional teams, including medicinal chemists and biologists, to design small molecules, optimize drug candidates, and accelerate the drug discovery process through advanced modeling and simulation techniques.

Key Responsibilities:

  • Develop and apply computational chemistry strategies for drug design and discovery
  • Utilize molecular modeling, structure-based drug design (SBDD), and ligand-based drug design (LBDD) to identify and optimize novel compounds
  • Collaborate with medicinal chemists and biologists to inform structure-activity relationships (SAR) and guide synthesis efforts
  • Develop and refine predictive models to accelerate hit-to-lead and lead optimization processes
  • Oversee virtual screening, molecular dynamics simulations, and quantum chemical calculations to support oncology pipeline development
  • Mentor and manage a growing team of computational chemists
  • Stay updated on the latest advances in computational chemistry, machine learning, and AI-driven drug discovery

Qualifications:

  • Ph.D. in Computational Chemistry, Chemistry, or a related field
  • 7+ years of experience in computational drug discovery, with a focus on small molecules
  • Expertise in molecular modeling, SBDD, LBDD, and virtual screening
  • Proficiency with computational chemistry software (e.g., Schrödinger, OpenEye, MOE) and molecular dynamics tools
  • Experience in oncology drug discovery is highly desirable
  • Proven leadership and team management skills
  • Strong collaboration and communication skills, with experience working in interdisciplinary teams

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