Senior Protein Chemist

Company Overview:

Conigen Bioscience Inc. is a leading entity in the life sciences sector, located in Worcester, MA. Our focus is on delivering innovative life science reagent tools that harness the latest advancements in immunology, virology, molecular biology, and cell biology. We are dedicated to creating novel reagents and high-quality assays that facilitate the discovery of new therapeutics. Our work environment is dynamic and entrepreneurial, emphasizing automation-driven solutions. We seek individuals who are collaborative and persistent problem solvers, passionate about making a significant impact in the field.

Position Overview:

We are in search of an outstanding Protein Scientist to enhance our team. The ideal candidate will possess a robust background and specialization in protein chemistry, protein biology, and protein purification, particularly in a fast-paced laboratory setting.

Key Responsibilities:

• Design and engineer protein molecules, including both membrane-associated and soluble target proteins, utilizing both rational and innovative methodologies.
• Conduct thorough protein structure analysis and modeling with advanced software tools to investigate protein structures and sequences. Develop and optimize various protein and antibody expression and purification processes.
• Stay informed on the latest advancements in protein engineering technologies and relevant literature.
• Contribute to new product development initiatives by enhancing existing protein purification downstream processes to improve product quality.
• Execute laboratory experiments aimed at developing, evaluating, or transferring methods and procedures, with a specific focus on protein purification and analysis.
• Prepare protein samples for statistical collection, processing, and structural refinement.
• Establish and enhance the foundation of protein-protein interaction bioassays by providing scientific and technical support.
• Conduct comprehensive data analysis and interpretation.
• Prepare abstracts and present findings at scientific conferences. Maintain and develop laboratory procedures, documentation, and organizational processes, including annual cleanouts and equipment calibrations.
• Work closely with scientists to identify and resolve workflow bottlenecks, inefficiencies, and areas for improvement.
• Communicate findings and the significance of data with a multidisciplinary team, including upstream and downstream process development scientists, quality control, quality assurance, process engineers, and clients.
• Proactively identify, troubleshoot, and resolve laboratory-related issues, including addressing off-hours emergencies.
• Perform complex laboratory experiments and additional duties as necessary.
• Utilize relevant software for experiments and equipment, ensuring accurate record-keeping.
• Maintain a detailed laboratory notebook and precise records in accordance with Good Laboratory Practices (GLP).
• Provide mentorship to junior scientists in research and development.
• Guide junior scientists in maintaining a detailed lab notebook and adhering to good laboratory practices (GLP).
• Collaborate within an interdisciplinary team of scientists, contributing skills and insights to various projects.

Qualifications:

• PhD in Protein Chemistry, Biochemistry, Immunology, Virology, or a related discipline.
• Minimum of 3 years of post-doctoral experience in protein chemistry, expression, purification, and protein engineering, with knowledge of protein structure analysis.
• Expertise in designing and engineering membrane-associated and soluble proteins and tags.
• Experience in expressing and purifying membrane proteins, viral-like particles, and soluble proteins, preferably with the AKTA system.
• Familiarity with mammalian cell culture and transfection, along with a solid understanding of cell biology.
• Technical proficiency in protein-protein interaction assays, including solid-phase binding, binding kinetics, affinity measurements, fluorescence, and bead-based assays.
• Strong background in molecular biology techniques such as mammalian expression construct design, PCR, and RT-PCR.
• High attention to detail, eagerness to learn new skills, and commitment to quality standards.
• Demonstrated ability to actively solve problems, think critically and creatively, and work independently on prioritized tasks.
• Excellent interpersonal skills and a willingness to collaborate in a highly cross-functional team environment.
• Strong team player with the ability to engage in professional discussions with individuals of diverse personalities and work styles.
• Exceptional organizational, verbal, and written communication skills.

Conigen Bioscience is an Equal Opportunity employer and does not discriminate against applicants or employees based on race, creed, color, religion, sex, national origin, ancestry, age, sexual orientation, physical or mental disability, or veteran status.

The responsibilities outlined in this job description are intended to illustrate the various types of work that may be performed. The omission of specific duties does not exclude them from the position if the work is similar, related, or logically assigned to the role.