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Senior Protein Chemist
2 months ago
About Conigen Bioscience:
Conigen Bioscience Inc. is a pioneering life science reagent tools enterprise located in Worcester, MA. Our advanced platform combines state-of-the-art immunology, virology, molecular biology, and cell biology to create innovative reagents and high-quality assays for a diverse array of targets, propelling the advancement of therapeutic discoveries. We are driven by a dynamic, entrepreneurial ethos and embrace solutions powered by automation. We seek collaborative and tenacious problem solvers who are passionate about making a significant impact.
Position Overview:
We are in search of an outstanding Protein Scientist to enhance our team. The ideal candidate will possess a solid background and expertise in protein chemistry, protein biology, and protein purification within a fast-paced laboratory setting.
Key Responsibilities:
- Design and develop protein molecules, including both membrane-associated and soluble target proteins and tags, utilizing both rational and innovative strategies.
- Conduct protein structure analysis and modeling using cutting-edge software to investigate protein structures and sequences. Engage in various forms of protein and antibody expression, along with purification process development and optimization.
- Stay informed on the latest advancements in protein engineering technology and relevant literature.
- Contribute to new product development strategies by enhancing current protein purification downstream processes to ensure product quality.
- Execute laboratory experiments aimed at developing, evaluating, or transferring methods and procedures, with a focus on protein purification and analysis.
- Prepare protein samples for statistical collection, processing, and structural refinement.
- Establish and develop the foundation for protein-protein interaction bioassays by offering technical and scientific support.
- Perform comprehensive data analysis and interpretation.
- Prepare abstracts and present findings at scientific conferences. Maintain and develop laboratory procedures, documentation, and organizational processes, including routine cleanouts and equipment calibrations.
- Work closely with scientists to identify and resolve workflow bottlenecks, inefficiencies, and opportunities for improvement.
- Communicate findings and discuss data relevance with a multidisciplinary team comprising upstream and downstream process development scientists, quality control, quality assurance, process engineers, and clients.
- Proactively identify, troubleshoot, and resolve laboratory-related issues, including addressing off-hours emergencies.
- Conduct complex laboratory experiments and fulfill additional responsibilities as needed.
- Utilize relevant software for experiments and equipment, ensuring accurate record-keeping.
- Maintain a detailed laboratory notebook and accurate records in accordance with Good Laboratory Practices (GLP).
- Provide mentorship to junior scientists in research and development.
- Guide junior scientists in maintaining detailed laboratory notebooks and adhering to Good Laboratory Practices (GLP).
- Collaborate within an interdisciplinary team of scientists, contributing skills and insights to various projects.
Qualifications:
- PhD in Protein Chemistry, Biochemistry, Immunology, Virology, or a related discipline.
- Minimum of 3 years of post-doctoral practical experience in protein chemistry, expression, purification, and protein engineering; familiarity with protein structure analysis.
- Expertise in designing and engineering membrane-associated and soluble proteins and tags.
- Proficient in expressing and purifying membrane proteins, viral-like particles, and soluble proteins; experience with AKTA systems is preferred.
- Experience in mammalian cell culture and transfection, with a solid understanding of cell biology.
- Technical proficiency in protein-protein interaction assays, including solid-phase binding, binding kinetics, affinity measurements, fluorescence, and bead-based assays.
- Strong command of molecular biology techniques such as mammalian expression construct design, PCR, and RT-PCR.
- High attention to detail, eagerness to learn new skills, and commitment to quality standards.
- Demonstrated ability to actively solve problems, think critically and creatively, and work independently on established priorities.
- Excellent interpersonal skills and a willingness to collaborate within a highly cross-functional team environment.
- Strong team player with the ability to engage in professional discussions with individuals of diverse personalities and work styles.
- Exceptional organizational, verbal, and written communication skills.
Conigen Bioscience is an Equal Opportunity employer and does not discriminate against any applicant or employee based on race, creed, color, religion, sex, national origin, ancestry, age, sexual orientation, physical or mental disability, or veteran status.
The responsibilities outlined in this job description are intended to illustrate the various types of work that may be performed. The omission of specific duties does not exclude them from the position if the work is similar, related, or logically assigned to the role.
