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Senior Protein Chemist
2 months ago
About Conigen Bioscience:
Conigen Bioscience Inc. is a pioneering life science reagent tools organization located in Worcester, MA. Our advanced platform combines innovative immunology, virology, molecular biology, and cell biology to create novel reagents and high-quality assays for a wide array of targets, facilitating the advancement of therapeutic discoveries. We thrive in a dynamic, entrepreneurial environment and embrace solutions driven by automation. We are in search of collaborative and tenacious problem solvers who share our commitment to making a significant impact.
Position Overview:
We are seeking to enhance our team with an outstanding Protein Scientist. The ideal candidate will possess a solid track record and specialized knowledge in protein chemistry, protein biology, and protein purification within a fast-paced laboratory setting.
Key Responsibilities:
- Design protein molecules, including both membrane-associated and soluble target proteins and tags, utilizing both rational and creative methodologies.
- Conduct protein structure analysis and modeling using state-of-the-art software to investigate protein structures and sequences. Engage in various forms of protein and antibody expression and purification process development and optimization.
- Stay informed on the latest advancements in protein engineering technology and relevant literature.
- Contribute to new product development strategies by innovating or enhancing current protein purification downstream processes to elevate product quality.
- Execute laboratory experiments aimed at developing, evaluating, or transferring methods and procedures, with a specific focus on protein purification and analysis.
- Prepare protein samples for statistical collection, processing, and structural refinement.
- Establish and enhance the foundation of protein-protein interaction bioassays by offering technical and scientific support.
- Perform comprehensive data analysis and interpretation.
- Prepare abstracts and present findings at scientific conferences. Maintain and develop laboratory procedures, documentation, and organizational processes, including annual cleanouts and equipment calibrations.
- Work closely with scientists to identify and resolve workflow bottlenecks, inefficiencies, and opportunities for improvement.
- Communicate findings and discuss data relevance with a multidisciplinary team comprising upstream and downstream process development scientists, quality control, quality assurance, process engineers, and clients.
- Proactively anticipate, troubleshoot, and resolve laboratory-related issues, including responding to off-hours emergencies.
- Conduct complex laboratory experiments and fulfill additional duties as required.
- Utilize all relevant software for experiments and equipment, ensuring accurate record-keeping.
- Maintain a detailed laboratory notebook and precise records in accordance with Good Laboratory Practices (GLP).
- Provide mentorship to junior scientists in research and development.
- Guide junior scientists in maintaining detailed laboratory notebooks and accurate records following good laboratory practices (GLP).
- Collaborate within an interdisciplinary team of scientists, contributing skills and insights to various projects.
Qualifications:
- PhD in Protein Chemistry, Biochemistry, Immunology, Virology, or a related field.
- Minimum of 3 years of post-doctoral practical experience in protein chemistry, expression, purification, and protein engineering; knowledge in protein structure analysis.
- Expertise in designing and engineering membrane-associated and soluble proteins and tags.
- Proficient in the expression and purification of membrane proteins, viral-like particles, and soluble proteins; experience with AKTA systems is preferred.
- Experience in mammalian cell culture and transfection, with a solid understanding of cell biology.
- Technical proficiency in protein-protein interaction assays, including solid-phase binding, binding kinetics, affinity, fluorescence, and bead-based assays.
- Strong background in molecular biology techniques such as mammalian expression construct design, PCR, and RT-PCR.
- High attention to detail, eagerness to learn new skills, and adherence to quality standards.
- Demonstrated ability to actively solve problems, think critically and creatively, and work independently on established priorities.
- Excellent interpersonal skills and a willingness to collaborate within a highly cross-functional team environment.
- Strong team player with the ability to engage in professional discussions with individuals of diverse personalities and work styles.
- Exceptional organizational, verbal, and written communication skills.
Conigen Bioscience is an Equal Opportunity employer and does not discriminate against any applicant or employee based on race, creed, color, religion, sex, national origin, ancestry, age, sexual orientation, physical or mental disability, or veteran status.
The responsibilities outlined in this job description are intended to illustrate the various types of work that may be performed. The omission of specific duties does not exclude them from the position if the work is similar, related, or logically assigned to the role.
