Biologics Engineer

4 weeks ago

Cambridge, Massachusetts, United States Fable Therapeutics Full time
About Us:

Fable Therapeutics is a pioneering biotechnology company that harnesses the power of AI to revolutionize protein-based therapeutics.

We are driven by a passion for innovation and a commitment to solving complex medical challenges. Our team of experts is dedicated to developing purpose-built biologics that overcome therapeutic index limitations and channel therapeutic response where and when it matters.

With a strong foundation in machine learning and biotechnology, we are poised to lead the next chapter in protein-based therapeutics.

Job Summary:

We are seeking a highly skilled and motivated Biologics Engineer to join our growing team. As a key member of our Biologics Engineering team, you will be responsible for enabling antibody-based constructs and production from our bespoke AI-designed antibody libraries using eukaryotic systems.

You will have the opportunity to contribute to designing the ideal lab environment to support your library and molecule building workflows, including molecular biology and robotics/automation. The data you generate will be used to train our state-of-the-art ML platform to design potent and drug-like antibodies.

Responsibilities:
  • Generation of antibody-based constructs and libraries from AI-designed sequences
  • Molecular Biology, DNA vector designs and DNA cloning capabilities
  • DNA sequence analysis
  • Subcloning of hits into mammalian expression vectors
  • Site-directed mutagenesis
  • Expression and purification of antibody constructs in mammalian cell culture at micro, medium and large scale as appropriate
  • Binding assays based on FACS, flow cytometry and ELISA
  • Careful documentation and record-keeping of scientific results
  • Molecule registration and inventory, and data upload to databases and LIMS systems
  • Curation of data for ingestion and utilization by ML scientists
About You:
  • BA in Molecular Biology or Protein Engineering and 4+ years industry experience in biologics discovery and protein science OR MSc and 2+ years experience
  • Excellent molecular biology, DNA cloning and protein engineering skills
  • Familiarity with liquid handling systems and high-throughput screening systems
  • Committed to digital workflows and the lab of the future
  • Ability to work efficiently in a close-knit team and deliver high quality, reproducible data in a fast-paced environment
  • Attentive to detail and a careful experimenter
  • Ability to take initiative and improve processes
  • An excellent communicator and presenter of scientific data
  • Passionate about the power of AI to transform biotherapeutics
  • Focused on quantifiable results and data-driven decisions
  • Collaborative and inclusive mindset

We are an equal opportunity employer and we value diversity and inclusion. Fable Therapeutics provides an open, collegial, and friendly work environment where we empower people and provide them with opportunities to develop their long-term careers.

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