Senior Cell Biologist/Engineer
2 days ago
Draper Labs is seeking a highly skilled Senior Cell Biologist/Engineer to join our Bioengineering Division. As a key member of our team, you will be responsible for developing and deploying multidisciplinary solutions at the convergence of biology and engineering to address critical needs in national security and healthcare.
Key Responsibilities:- Serve as a subject matter expert in cell biology and/or tissue bioengineering, with a focus on lung, liver, gastrointestinal, neural, and/or lymphoid tissue biology.
- Plan and execute hands-on experiments in a BSL-2 lab using Draper's novel in vitro platform technologies (microphysiological systems or organs-on-chip).
- Lead mammalian cell and tissue culture and assay development, and assist in troubleshooting experimental work as needed.
- Analyze, report, and present experimental data to internal management, external customers, and/or for publication.
- Work across a broad spectrum of engineering and biological applications to solve our customers' most challenging needs, including biodefense/biosecurity and medical countermeasure development applications.
- Multitask within a dynamic and diverse project environment and adapt to changing priorities.
- PhD in biomedical engineering, cell biology, stem cell biology, immunology, or a related field, with a demonstrated understanding of human cell and tissue biology and advanced in vitro cell culture platforms.
- Expertise in primary mammalian cell and tissue culture (human or animal), including complex multi-cell type co-culture, 3D cell culture/organoid biology, and/or stem cell culture.
- Experience engineering tissue with resident immune cell populations, i.e. immune-competent tissue models.
- Experience with primary-derived cell culture differentiation methodologies, phenotypic and functional characterization of tissue-specific and/or immunological cells, and/or identification and/or understanding of key biomarkers for core tissue cell populations, and/or tissue-resident or blood-derived immune cell populations.
- Expertise applying fundamental biology knowledge to novel in vitro cell culture systems such as microphysiological systems or organs-on-chip.
- Experience with standard cell and molecular biological assays such as ELISA/Luminex, nucleic acid extraction, qPCR, immunofluorescence staining and confocal microscopy, cell proliferation/viability assays, cytotoxicity assays, flow cytometry / FACS, magnetic cell sorting.
- Ability to solve complex problems with minimal supervision, adapt to changing priorities, interface with all levels of internal management, as well as program sponsors and subcontractors.
- Tissue engineering experience, specifically pulmonary, liver, gastrointestinal, neural, and/or lymphoid tissues.
- Experience with microfluidic devices, microphysiological systems, and/or organs-on-chip technologies.
- Microbiology experience, such as in vitro or in vivo experience with BSL2 or BSL3 viruses, bacteria, or toxins; experience studying host-pathogen interactions; experience studying or modeling.
- Expertise in molecular biology, mucosal immunology, multi-omics, bioinformatics and data analytics, biostatistical analyses, stem cell and iPSC biology, and/or laboratory automation.
- Experience isolating and characterizing cells such as epithelial, endothelial, and/or immunological (B cells, T cells, monocytes).
- Prior experience in the biotechnology industry, a plus.
- Some experience writing innovative R&D proposals for government sponsors (contacts, grants) or commercial sponsors and/or generating intellectual property.
- Interest in helping to support business development efforts through ideation, proposal writing, and customer outreach, including strategic interfaces with biotech and academic groups.
Applicants selected for this position may be required to obtain and maintain a government security clearance. Draper is an equal opportunity employer and welcomes applications from diverse candidates. We are committed to creating a diverse environment and are proud to be an affirmative action and equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, disability, age, sexual orientation, gender identity, national origin, veteran status, or genetic information.
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