Quantitative Systems Pharmacology Lead

4 weeks ago


Waltham, Massachusetts, United States GlaxoSmithKline Full time
Job Description

We are seeking a highly motivated and experienced Quantitative Systems Pharmacology Lead to join our Clinical Pharmacology Modelling and Simulation (CPMS) department at GlaxoSmithKline.

The successful candidate will be responsible for developing and applying Quantitative Systems Pharmacology (QSP) models to guide clinical study designs and mechanistic interpretation of study results in support of development of treatments and combination of treatments for a variety of diseases and therapeutic areas.

The role will involve working closely with biologists, clinicians, clinical pharmacologists, pharmacometricians, QSP and nonclinical modelers, and other partner line colleagues to inform research and development programs and improve our understanding of disease mechanisms.

Key Responsibilities:

  • Build and utilize QSP models of biological, physiological, and pathophysiological processes to evaluate a disease, its pathways and progression, as well as drug candidates or treatment modalities.
  • Work in close collaboration with cross-functional teams to inform research and development programs and improve our understanding of disease mechanisms.
  • Develop and/or utilize state-of-the-art mathematical tools to gain insight into causal relationships between individual components of system-level and drug-level responses of drug-target-biomarker-disease-patient interaction.
  • Analyze and interpret complex data sets in the context of disease mechanisms and pathways.
  • Explore new QSP opportunities in combining QSP with other analytical approaches and build synergies through collaboration with computational groups including human genetics and functional genomics.
  • Provide both scientific and strategic expertise in oncology therapeutic area to facilitate, develop and deliver quantitative support for decision making in clinical development programs.

Requirements:

  • PhD in Applied Mathematics, Engineering, Pharmaceutical Sciences, Systems Biology, or related disciplines with experience in the application of mathematical and statistical methods.
  • 2 or more years of experience in Pharma Life Science Biomedical industry developing and applying QSP approaches to drug development programs.
  • Experience working with the theory, principles, statistical aspects of mathematical modeling and simulation, including numerical methods, parameter estimation/optimization, ordinary differential equations (ODEs), and how these can be applied in the development of complex models of biological pathways and systems.
  • Computational experience with one or more modeling and simulation packages or programming languages (e.g., MATLAB, R, Julia, SimBiology, C/C++).
  • Experience working with common tools for quantitative clinical pharmacology (such as NONMEM, R, WINNONLIN, Simcyp, SAS).
  • Experience developing mechanistically-sound PK-PD models.
  • Experience translating, condensing, summarizing outcomes of modeling and simulation analyses into information that can be understood by project teams.

Preferred Qualifications:

  • Demonstrated collaborative ways of working and able to work successfully in matrix teams.
  • Ability to effectively communicate and interact with key stakeholders, medical professionals and senior leadership.
  • Ability to learn new areas of biological sciences and build on solid foundation of quantitative skills.


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