Associate Director Research In Vitro Antibody Discovery
2 days ago
At Takeda Pharmaceutical Company Limited, we are a forward-thinking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients worldwide. As an Associate Director Research In Vitro Antibody Discovery, you will have extensive expertise and a comprehensive understanding of antibody discovery, optimization through in vitro based methodologies, and advancing programs from discovery towards IND. You will be responsible for leading a small team of scientists with an enterprise mindset, allocating resources to high-priority programs, and collaborating with matrix teams to best enable programs. Your exceptional leadership skills, technical proficiency, and collaborative approach will be essential for effective team management. You will also have proficiency in antibody yeast display methods, a keen attention to technical detail, and excellent knowledge of phage methods. Integration of NGS/functional based datasets to mine and improve molecules, along with pro-activity in lead optimization approaches for best therapeutic needs, is a must. Experience with monospecific/mAbs, bispecifics, and single domain antibodies is required. As part of the Biotherapeutic Engineering team, you will report to the Senior Director of the team and be an organizational leader who has accountability for the performance and results of a small team. You will recognize and streamline the most efficient ways of working, which requires tremendous drive, motivation to deliver (and beat) team and program goals, while also pushing the boundaries to enhance discovery and optimization. Working and networking excellently within the team is critical for best performance and team engagement.
Key Responsibilities:
- Scientific Leader:
- Set high standards for effectiveness of execution and rigor of thought. Possessing in-depth knowledge of antibody-based discovery, optimization/engineering using yeast/phage in vitro based discovery methods.
- Draw on expertise from in vitro based discovery platforms to provide thoughtful and innovative guidance on strategies towards candidate profiles for differing target types, optimization/engineering approaches to enhance properties to progress from lead to candidate.
- Experience in appropriately mining and triaging of antibody repertoires to progress viable therapeutic molecules. Appropriate incorporation of NGS based sequence analysis for both repertoires and clonal populations, while driven by functional readouts.
- Highly innovative but focused mindset to identify and drive efficient paths for workflow progression.
- Set excellent strategy within the sub-team and foster innovation.
- Contribute to continual deepening of the expertise through external network development.
- People Leader:
- Organizational leader who has accountability for the performance and results of a small team. Empowerment, but strong mentoring of that team in their mission to generate therapeutic biologics.
- Use enterprise mindset with a broad view across the portfolio that informs resourcing and prioritization of programs under direct remit, while responsible for working within the matrix team to best resource programs and drive forward in an efficient manner.
- Develop the next generation of scientists and leaders, acting as a champion of new opportunities. Team-centric mindset, inspiring and growing team members, while serving as a role model and mentor across the entire group.
- Lead team through in-lab presence, designing and efficiently executing discovery/optimization campaigns including affinity maturation, developability; technology development.
- Program Involvement:
- Ambassador for the biologics department, scientifically inputting to project teams, helping set standards for excellent and focused triage of molecules.
- Exceptionally collaborative mindset with interact with internal/external groups for high efficiency and transparency to enable swift progression of molecules.
- Other:
- Excellent knowledge of data analysis tools to ensure thorough evaluation of datasets and information-based next-step decisions.
- High level of diligence in all data tracking, uploading, and recording using data management systems within the department.
- Key involvement and due diligence for external interactions, collaborations, and workflows where appropriate.
- Contribution to the preparation of patents, documentation for IND, and publications.
- PhD degree in a scientific discipline with 7+ years of experience, or MS with 13+ years of experience, or BS with 15+ years of experience. 5 years of industry experience required.
- 5 years of managerial experience required.
- Keeps up with the up-to-date scientific advancement (e.g. competitive landscape, new technology, new research portfolio, and new partnership).
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