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Head of Biochemical and Cellular Engineering
1 month ago
We are seeking a highly experienced and accomplished Head of Biochemical and Cellular Engineering to lead our team in developing innovative biochemical assays and cell-based screening technologies for our protein degradation drug discovery platform. As a key member of our scientific leadership team, you will be responsible for designing, implementing, and interpreting robust biochemical and cell-based assays to drive lead optimization and mechanism of action studies.
Key Responsibilities- Lead the scientific direction and operation of the Biochemical and Cellular Engineering Group, promoting innovative science through collaboration and teamwork.
- Contribute to multiple drug discovery projects via the design, implementation, and interpretation of robust biochemical and cell-based assays for lead optimization, HTS, and mechanism of action studies.
- Support projects and project teams by implementing robust in vitro cascades to deliver drug candidates.
- Identify, initiate, and manage collaborations with external collaborators and CROs, including assay development, execution, quality control, and handling of data.
- Employ rigorous data analysis techniques and ensure pharmacological data generated by the team is reviewed and reported in appropriate format to enable ease of access in appropriate databases.
- Serve as the scientific leader and subject matter expert (SME) in biochemical and cellular engineering on multiple project teams.
- Contribute to technical reports to support program reviews, patents, publications, and IND submissions.
- Stay up-to-date with emerging scientific literature.
- Collaborate and communicate across a diverse scientific team to successfully progress Lyterian goals.
- PhD in Biochemistry, Pharmacology, Cell Biology, Biology, Chemical Biology, or related discipline with 10+ years of relevant postdoctoral or industrial experience.
- Experience successfully initiating and executing high-quality biochemical and cell-based assays in medium/high-throughput formats for drug discovery.
- Strength in experimental design, assay development, execution, and expertise in several assay platforms to analyze target engagement and degradation (such as HTRF, luminescence, NanoBRET, CETSA, High Content Imaging, flow cytometry).
- Research experience with characterization of protein modification and turnover, and cellular mechanism of action studies.
- In-depth knowledge of modern in vitro pharmacology approaches and principles that contribute to successful delivery of candidate drugs.
- Ability to independently define key scientific questions and design rigorous experiments in collaboration with internal and external partners, including CROs.
- Familiar with data analysis software and databases for the handling of large datasets.
- Knowledge of protein degradation mechanisms and in particular the biochemistry of ubiquitin ligases is a plus.
- Excellent verbal and written communication skills, including strong formal presentation skills and the ability to communicate complex scientific information in an understandable manner.
- Evidence of scientific excellence and impact as illustrated by scientific publications and presentations.
- Initiative and boldness to dive into a fast-paced new startup.
We offer a competitive employment package that includes an annual bonus, significant equity, and a generous benefits package including comprehensive health, dental, and vision insurance for our employees and their families, plus a 401K match.
We are an equal opportunity employer and welcome candidates of all levels to apply. Compensation will be based on a variety of factors, including experience, qualifications, internal equity, and location.
