Scientific Investigator

4 days ago

Bar Harbor, Maine, United States The Jackson Laboratory Full time
About the Role

We are seeking a highly skilled and experienced Scientific Investigator to join our team at The Jackson Laboratory. This role will be the lead technical scientist in nucleic acid therapeutics design and development, working closely with our team of scientists to advance our mission to improve human health.

Key Responsibilities
  • Lead technical design and provide scientific expertise for oligonucleotide therapeutics.
  • Establish in vitro and in vivo ASO screening and validation protocols in cellular and animal models.
  • Perform manufacturing vendor evaluations and oversee outsourced work.
  • Lead an independent research program in rare disease therapeutic development, under the direction of RDTC leadership.
  • Work as part of cross-functional teams to evaluate, prioritize, validate and advance therapeutics projects to the clinic.
  • Collaborate with RDTC leadership, lab scientists and data scientists to develop and advance partnership and commercialization strategies.
  • Stay abreast of emerging technologies and regulatory landscapes in the field.
  • Lead gene-based therapy R&D projects to learn and advance the technology and assets.
  • Develop and oversee quality and process control adherence to technical specifications for ASO products.
  • Troubleshoot technical issues and devise solutions.
  • Serve as a subject matter expert, submitter and superuser for the utilization, development, expansion and integration of relevant oligonucleotide database platforms and repositories.
  • Contribute to or lead grants.
  • Contribute to or lead collaborative research projects and publications.
  • Communicate effectively to manage internal and external relationships.
Requirements
  • PhD in Chemistry, Biochemistry, Chemical Engineering, Biology or a related discipline, with 5+ years of experience beyond the doctoral degree.
  • Extensive experience in oligonucleotide or synthetic peptide design.
  • Proven abilities in data-driven decision-making and problem-solving.
  • Strong knowledge of quality process control and vendor quality assessments.
  • Ability to lead independent research initiatives, analyze experimental data, and interpret results.
  • Experience working with cross-functional teams in the development and use of databases.
  • Experience in securing and managing research grants and budgets.
  • Strong mentorship skills to guide graduate students, postdoctoral researchers, and other team members.
  • Ability to collaborate with interdisciplinary teams and external partners.
  • Understanding of regulatory pathways and compliance.
  • Creative problem-solving skills in research and experimental design.
  • Commitment to ethical research practices and adherence to safety protocols.
  • Focus on rare diseases and translational research to improve human health.
  • Effective budget management and laboratory maintenance skills.
  • Excellent communication skills for managing collaborations and presenting findings.
About The Jackson Laboratory

The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute-designated Cancer Center and nearly 3,000 employees in locations across the United States, Japan, and China. Our mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.

We apply over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging, and heart disease. We model and interpret genomic complexity, integrate basic research with clinical application, educate current and future scientists, and provide critical data, tools, and services to the global biomedical community.

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