(Associate) Director

2 weeks ago

Boston, United States StealthMode Full time

Company Overview: This stealth mode company is pioneering novel small-molecule therapies that drive programmable, sequence-specific edits to the epigenome to treat diseases with broad impact. Our therapeutics platform is based on small molecule epigenome editors (Epitors) that are readily programmed to bind specific DNA sequences and recruit epigenetic regulators (e.g. histone acetyltransferase, DNA methyltransferase) locally to drive therapeutically-relevant epigenetic changes at defined sites via induced proximity. The platform can yield a suite of Epitors that either upregulate healthy genes/reactivate silenced genes (ON-Epitors) or silence disease-causing genes (OFF- Epitors). The small-molecule properties (broad biodistribution, scalability) and DNA sequence selectivity together make a powerful combination that has the potential to vastly expand the capability & utility of epigenome editing, which is currently limited by delivery issues encountered by existing gene therapy-based approaches. This unlocks epigenome editing as a therapeutic strategy for many conditions in oncology, immunology, metabolic diseases, and genetic diseases. Job Responsibilities: Support discovery and translation efforts, with a focus on building datasets, algorithms, computational pipelines and data storage and mining solutions for big data generated from our proprietary platforms along with public source data. Apply next-generation DNA and RNA sequencing and bioinformatics capability, and additional molecular approaches as appropriate, to provide enhanced understanding of on- and off-target events for epi / genetic editing approaches. Develop and / or implement computational tools for CRISPR on- and off-target editing. Work in collaboration with Biology and Chemistry teams to produce new tools and databases. Perform analysis of large-scale -omics datasets (e.g., RNA-Seq, ChIP-Seq) and derive scientifically meaningful interpretations. Be available to others as a general bioinformatics resource at the company. Professional Experience/Qualifications: PhD in Computational/Informatics, Biostatistics or related discipline with a minimum of 5 years of biopharmaceutical industry experience. Data science programming expertise using R, Python, etc., and experience with data processing, statistical analysis, and data visualization including in a cloud environment. Expertise in -omics research that includes knowledge that covers some subset of analytical domains, e.g., single cell, spatial, multiomics, gene expression, gene regulation, genomic assembly, genetic variation, and public data repository mining. Demonstrated record of developing computational pipelines to analyze DNA high- throughput sequencing data and usage of common bioinformatics tools. Excellent communication and presentation skills. Experience in data visualization. Team player with ability to work successfully across disciplines. Additional desirable experience: Experience in genetic screening library design.

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