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Research Scientist

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Boston, United States Massachusetts General Hospital Full time

Job Description - Research Scientist (3299058) Summary: The Ragon Institute is a highly unique, innovative, and collaborative research center at the forefront of biomedical science. Founded by Massachusetts General Hospital, MIT, and Harvard, the Ragon vision is to harness the power of the immune system to prevent and cure human disease on a global scale. This vision is pursued by a group of highly motivated individuals who embrace collaboration, compassion, dedication, and innovation. The Idris Lab focuses on malaria research, aiming to address knowledge gaps surrounding the mechanisms that underlie durable immunity against malaria. Our lab seeks to reveal the vulnerabilities of this parasite and understand its impact on the host immune response. These insights have led to the discovery of potent monoclonal antibodies that target the pre-erythrocytic stage of the parasite’s life cycle. By leveraging in vitro and in vivo models and studying naturally exposed and vaccinated human cohorts, we aim to identify novel targets for the development of more effective antibodies and vaccines. We are currently seeking a highly ambitious, adaptable, structured, and detail-oriented Malaria Parasitologist to join our dynamic team. The successful candidate will play a crucial role in advancing our understanding of malaria immunity and contribute to the development of novel anti-malarial biologics. Organize and maintain Plasmodium frozen stocks for mosquito infections. Monitor mosquito infection status: blood feeding, natural transmission, and parasite isolations. Conduct mosquito dissections to isolate midguts (oocysts) and salivary glands (sporozoites). Maintain malaria-infected mosquito colonies and conduct in vivo malaria challenge experiments in rodents. Evaluate the efficacy of malaria vaccines and antibodies in mouse models. Design rodent malaria layouts/challenges to establish new protocols, procedures, doses, and risks for malaria experiments. Conduct pre-clinical evaluation (PK and PD experiments) for malaria vaccines and monoclonal antibodies. Collect, analyze, interpret, and report data for presentations, reports, and publications. Record procedures and research project data in accordance with regulations. Monitor and maintain laboratory supplies; prepare purchase requests. Perform routine maintenance of lab work areas and specialized instruments. Supervise and train technicians and other personnel as needed. Minimum Requirements: Minimum degree and field of knowledge: PhD Years experience required: 3+ years experience PhD in immunology, parasitology, cell biology, microbiology, biochemistry, or a related field. Three or more years of experience working with malaria. Proficiency in routine technical procedures in mice. Experience in preclinical malaria mouse challenge models, mosquito dissection, IVIS imaging, flow cytometry, fluorescence microscopy, antibody/protein purification, ELISA, ELISPOT. Strong adherence to safety standards and lab policies. Excellent oral and written communication skills. Basic skills in applicable computer programs. Ability to work independently and collaboratively in a team. Strong organizational skills, attention to detail, and the ability to handle multiple tasks in a fast-paced environment. Massachusetts General Hospital is an Affirmative Action Employer. By embracing diverse skills, perspectives, and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. #J-18808-Ljbffr