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Research Associate, Invivo Pharmacology
3 months ago
**Company Summary**: Korro is a biopharmaceutical company focused on developing a new class of genetic medicines for both rare and highly prevalent diseases using its proprietary RNA editing platform. Korro is generating a portfolio of differentiated programs that are designed to harness the body’s natural RNA editing process to effect a precise yet transient single base edit. By editing RNA instead of DNA, Korro is expanding the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability. Using an oligonucleotide-based approach, Korro expects to bring its medicines to patients by leveraging its proprietary platform with precedented delivery modalities, manufacturing know-how, and established regulatory pathways of approved oligonucleotide drugs. Korro’s main therapeutic area is Alpha-1 Antitrypsin Deficiency (AATD). Korro is based in Cambridge, Massachusetts.
We are collaborative and united by a common mission. We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases. Our values - _Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity _form the fabric of the organization. They are reinforced daily and serve as key dimensions in the hiring process to help us ensure that Korro is a magnet for outstanding talent and a great place to work. Join us as we redefine what's possible in genetic medicine and work to make a lasting impact on human health.
**Position Summary**: Korro Bio is seeking a highly motivated Senior Research Assistant/Associate Scientist to join our _Invivo_ Pharmacology team. The Associate Scientist will have the opportunity to work with an enthusiastic team of highly skilled scientists in a dynamic, matrixed organized, high growth company.
**Key Responsibilities**:
- Conduct experiments to determine the efficacy of novel oligonucleotides in models across a range of disease indications.
- Perform dosing (SC, IP, IM and IV), monitor animal health, blood sampling, multiple tissue harvesting and data recording. Coordinate sample storage and analysis.
- Provide overall _in vivo_ and _ex vivo_ technical support for projects working to advance one or more experimental therapeutic compounds.
- Responsible for carefully documenting research and effectively communicating results across teams.
- Plan and execute _in vivo_ studies in collaboration with research scientists.
**Required Qualifications**:
- BA/BS or MS with 3-5 years' experience in the biotechnology or pharmaceutical industry or academic equivalent.
- Knowledge of tissue processing and molecular biology methods (RNA purification, PCR, qPCR, sequencing, ELISA (MSD) and western blot).
- Experience running mouse models, including mouse handling, health monitoring, dosing and working with models of disease is highly desired.
- Skilled in various methods of dosing (IV, SC, IM and IP), blood collection (tail vein/submandibular and cardiac puncture) and multiple tissue collection at necropsy for subsequent _ex vivo _
- Desire and drive to learn and understand the basic biologic mechanisms underpinning our products.
- Experience in oligonucleotide-based therapeutics or gene editing is a plus
- Relevant CNS related experience beneficial but not necessary
- Exposure to utilizing software such as Graph Pad Prism, Microsoft office, Excel, and electronic laboratory notebooks for data analysis and data summary.
- Attention to detail with excellent organizational, time management and data recording skills.
- Highly motivated and able to be flexible in case of changing priorities.
- Able to thrive in a highly collaborative, fast-paced, team-oriented environment with colleagues from diverse disciplines.
- Effective verbal and written communication skills.
- Detail-oriented and excellent problem-solving abilities.
**Benefits**:Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance, a dependent care flexible spending account and a Company-funded health savings account and free parking.
