Principal Associate Scientist/Senior Principal Associate Scientist, Hit Identification and Biology

2 weeks ago

Waltham, United States Dragonfly Therapeutics Full time
Principal Associate Scientist/Senior Principal Associate Scientist, Hit Identification and Biology

Dragonfly Therapeutics seeks an experienced and motivated Principal/Senior Principal Associate Scientist with a strong background in cell biology/immunology to support the discovery and development of cancer and autoimmune therapies. The successful candidate will work with Dragonfly's Hit Identification Team developing cell reagents and performing functional screening assays. In addition, the candidate will assist the flow cytometry core manager with daily operations and maintenance. The individual will support the Biology group in the pre-clinical development of novel biologic drugs that promise to revolutionize disease treatment.

Responsibilities:
  • Maintain mammalian tissue culture, including adherent/suspension cell lines and primary cells
  • Execute cell line engineering workflows (CRISPR, viral transduction, transfection) to support antibody discovery and screening/characterization
  • Drive the development and implementation of cell-based screening and characterization assays to support therapeutic candidate selection
  • Perform multi-color cytometry experiments and data analysis
  • Assist with the daily operations of the flow cytometry core, including performing scheduled instrument maintenance
  • Analyze, interpret and communicate laboratory results within Hit ID team, the Biology group and Research department
  • Manage daily work flow independently and seek advice when appropriate
  • Maintain a detailed and up to date electronic lab notebook

Qualifications:
  • BS or MS degree in Cell Biology, Immunology, Bioengineering or relevant field (title commensurate with years of experience)
  • 3+ years of relevant research experience; industry experience (1+ years)
  • Strong understanding of immunology and cellular engineering
  • Expertise in mammalian cell culture and cell engineering using CRISPR and transduction/transfection techniques.
  • Experience with flow cytometry, cell sorting, and analysis of flow cytometry data is preferred
  • Strong organizational and time-management skills
  • Excellent verbal and written communication and interpersonal skills to work across functions
  • Ability to work within a team, coordinating with other scientists
  • Self-motivated, conscientious, and enthusiastic about helping patients

About Dragonfly

Dragonfly Therapeutics is a clinical-stage biopharmaceutical company committed to discovering, developing and commercializing therapies that use its novel multispecific antibody technology to harness the body's immune system to bring breakthrough treatments to patients. In addition to its wholly owned clinical assets, Dragonfly has a deep pipeline of wholly owned preclinical candidates discovered using its proprietary platform, as well as productive collaborations with Merck, AbbVie, Gilead and Bristol Myers Squibb in a broad range of disease areas.

Our mission is to revolutionize disease treatment by inventing natural killer cell-based therapies for vastly improved patient outcomes. We believe in a small team with a big impact.

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