Sr. Research Associate/Principal Research Associate

2 weeks ago

Waltham, United States Lucy Therapeutics Full time

Who is Lucy Therapeutics?

Lucy Therapeutics, a Boston-based biotech with a unifying mitochondrial platform, is seeking a thoughtful, creative Senior/Principal Research Associate to join our growing team At LucyTx, transparency, openness and opportunity are not just buzzwords - our CEO and team have made a commitment to providing a work environment where asking for help is celebrated, supporting others is rewarded, and finding new areas to create value is embraced.  


What is LucyTx doing?

Lucy Therapeutics is developing small molecule treatments to improve the lives of patients with devastating mitochondrial diseases such as Parkinson’s disease, Alzheimer’s disease and Rett syndrome. Our mitochondrial platform has led to the discovery of targets whose modulation can improve central energetic dysfunctions in these diseases and address their complex organ symptomatology with the potential for selectively in diseased vs. healthy cells. Our platform offers the potential for further target identification across a variety of neurological (and other) diseases. Read more about us here: 


Why join LucyTx?

We are looking for scientists who are curious - curious about the world around them, curious about how things work and how to solve problems. As a Senior/Principal Research Associate you will contribute to the design and execution of in vitro laboratory experiments and data analysis/interpretation required for advancing our drug discovery programs and expanding our mitochondrial platform. You will have the opportunity to develop further technical and leadership skills while working with an experienced drug discovery team who values integrity, teamwork, idea generation, diversity and scientists demonstrating the passion to make a difference in the lives of patients. 


What will you be doing at LucyTx?

  • Devise and conduct in vitro assays employing human and rodent cell-based/derived systems.
  • Actively contribute thoughts and ideas, design experiments, and implement new protocols to advance drug discovery programs.
  • Coordinate planning and acquisition of study materials, assay validation, troubleshoot assays and independently conduct rigorous data analysis and interpretation.
  • Independently contribute to research projects, communicating data, results and ideas with pharmacology team and aligning activities with team priorities and company goals. 
  • Create slides and conduct presentations highlighting assay development, experimental results and next steps at lab meetings; Learn and successfully present to different stakeholders including project and lab teams
  • Independently gather resources needed to fully execute experiments.
  • Maintain accurate and detailed laboratory records in an ELN for all experiments performed in accordance with company policy.
  • Provide scientific support for departmental/company presentations, and other activities as requested.
  • Regularly mine scientific literature for applications and research ideas that can be utilized to advance Lucy Therapeutics platform and programs.
  • Ensure compliance with all Lucy Therapeutics corporate policies and environmental health and safety policies and procedures.
  • Independently perform special projects as needed and requested.


What will you bring to LucyTx?  

  • BS or MS in biological sciences with 4+ years of relevant industry experience.
  • Experience working on drug discovery programs in neuroscience and preferably mitochondrial focused projects. Track record in Alzheimer’s disease research preferred. 
  • Experience developing assays using such techniques such as reporter assays, viability readouts, imaging, binding assays (such as Duolink, thermal shift) and/or metabolic analyses.
  • Strong cell culture and cell biology techniques required (primary neuron cultures, neuronal cell lines, astrocyte cultures and iPSc differentiation a plus) including qPCR, Western blotting, ELISAs, high-content imaging, and binding assays.
  • Experience with CRISPR, siRNA, transfection/transduction, and/or small molecule compound assessment.
  • Well versed in the use of data analysis and statistical tools (e.g. Excel, GraphPad Prism).
  • Passion for multi-tasking with ability to prioritize and organize workloads and tasks.
  • Highly organized with strong attention to detail and experience in generating rigorous and reproducible data sets.
  • Problem solver, who is creative and always looking for improvements and solutions.
  • Passion for bringing forward new ideas and approaches, continually integrating knowledge from literature and other data sources.
  • Willingness to ask questions and ability to work well in a team environment including cross-functional/multidisciplinary team settings.
  • Self-starter who actively pursues knowledge and skill development; operates with integrity; values diversity; flexible to contribute to multiple projects as needed; with a respectful sense of humor.


What else can LucyTx offer you?

Lucy Therapeutics offers comprehensive health and dental benefits, 401k plan, commuter benefits, unlimited paid time off, life insurance, parental leave, professional & employee development assistance and other perks to take care of our employees and provide a safe and comfortable working environment. We take time to understand our employees’ goals and aspirations and realize they will not all be the same. We will strive to let you contribute and achieve to your fullest


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