Principal Scientist, Protein Analytics

4 weeks ago

Waltham, United States Dragonfly Therapeutics Full time
Principal Scientist, Protein Analytics

Dragonfly Therapeutics is seeking a Principal scientist who brings enthusiasm, intellectual curiosity, scientific rigor, and a desire to help drive novel immunotherapy programs forward. The candidate must be independent, goal-oriented, flexible, and able to work efficiently across multiple projects. We are searching for enthusiastic and innovative individuals with a deep scientific interest in immunotherapy and drug discovery, who thrive in a fast-paced, entrepreneurial environment.

Responsibilities:
  • Provide mass spectrometry support of antibodies, TriNKETs, and recombinant proteins, including intact mass, peptide mapping, post-translational modification identification, disulfide mapping, de novo sequencing, and glycan profiling/identification of released glycans. Support developability studies by identifying and quantifying the chemical modification of amino acids after stress
  • Leverage expertise in protein mass spectrometry to answer critical questions throughout all phases of biologics development
  • Ensure mass spectrometry instruments are maintained
  • Serve as mentor to junior scientists and provide training/troubleshooting for routine intact mass analysis
  • Interpret results and communicate with cross-functional colleagues and external partners
  • Prepare technical reports, internal, and external presentations
  • Author / review relevant sections of regulatory submissions (IND/IMPD) and respond to questions from regulatory agencies
  • Identify, evaluate, and implement new and existing mass spectrometry-based technologies to improve protein characterization capabilities, throughput, and quality
  • Ensure effective, high-quality, timely and appropriate documentation in electronic laboratory notebooks
  • Prepare reagents, buffers, and equipment as needed to support experiments
  • Additional duties and responsibilities as required

Qualifications:
  • Ph.D. in Chemistry, Biochemistry, Biochemical Engineering, or equivalent related fields with 7+ years relevant industry experience
  • Proven experience in protein mass spectrometry including previous experience with Thermo and Waters mass spectrometers and Protein Metrics data analysis software
  • Experience with characterization of proteins with additional techniques such as CD, AUC, DSF, DSC, SEC-MALS, DLS/SLS, CE, cIEF, HPLC-based assays (SEC, HIC, IEX, etc.) is desirable
  • The candidate should be self-motivated, accountable, inquisitive, and have excellent organization and communication skills
  • Ability to work in a fast-paced environment, meet deadlines, and balance multiple priorities

About Dragonfly

Dragonfly Therapeutics is a clinical-stage biopharmaceutical company committed to discovering, developing and commercializing therapies that use its novel multispecific antibody technology to harness the body's immune system to bring breakthrough treatments to patients. In addition to its wholly owned clinical assets, Dragonfly has a deep pipeline of wholly owned preclinical candidates discovered using its proprietary platform, as well as productive collaborations with Merck, AbbVie, Gilead and Bristol Myers Squibb in a broad range of disease areas.

Our mission is to revolutionize disease treatment by inventing natural killer cell-based therapies for vastly improved patient outcomes. We believe in a small team with a big impact.

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