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Associate Research Fellow, Primary Pharmacology Group

4 months ago

Groton, United States Pfizer Full time

Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

Pfizer is making significant investment in the creation of novel, first-in-class therapeutics for the Pfizer pipeline. We are seeking an exceptional in vitro pharmacologist and laboratory automation head to join the Primary Pharmacology Group (PPG) at our Groton, CT campus and drive expansion and strategic execution of Pfizer's internal HTS capabilities for small molecule lead identification across the diverse Discovery & Early Development portfolio. Your work will play a key role in addressing the critical task of rejuvenating the Pfizer research pipeline with innovative, differentiated First in Class programs in the years to come.

As an Associate Research Fellow, you will be at the center of our operations and you'll find that everything we do, every day, is in line with an unwavering commitment to quality. You will drive the rebuilding of Pfizer's internal HTS capability within the Discovery Sciences department and its implementation. You will oversee the deployment of capital to assemble a state of the art screening infrastructure and build a dedicated team of scientists with relevant skills to ramp up internal HTS capabilities while leveraging external CROs as required. Thus, this role requires technical excellence in the execution of disease relevant pharmacology approaches to support HTS, laboratory automation, and data strategies. Additional desired areas of expertise include high content imaging or analytical expertise in mass spectrometry.

The successful candidate will combine strong technical/scientific rigor, strategic planning, leadership and problem-solving skills with a demonstrated ability to build, energize and lead high-performing teams to drive impact across multiple drug discovery programs. This individual should therefore possess exceptional collaborative and written/verbal communication skills, a good sense of humor and be adept at building partnerships. The role will have high visibility across the research organization so an executive presence and ability to gain the respect of stakeholders is key.Through your expertise and extensive knowledge, you will be able to foster a culture that promotes innovation and thrives on doing better for patients and healthcare.

How You Will Achieve It

* We are seeking an experienced pharmacologist and automation specialist to build and lead the HTS laboratory to support small molecule drug discovery. The laboratory head will also be responsible for automation and data management and lifecycle strategies within PPG.


* As the HTS portfolio lead, you will be responsible for management, communication, and execution of the HTS portfolio as well as and the strategic vision for HTS moving forward. This will include extracting value from HTS data beyond immediate project needs.
* This laboratory leader will maintain a 'cutting edge' awareness of technical developments and scientific advancements in the field and apply these innovatively to advance internal capabilities. The role includes opportunities to publish when appropriate.
* This HTS lead will lead interdisciplinary team(s) of biologists, medicinal chemists, and protein biochemists to effectively prosecute the HTS portfolio and actively interact with other groups in Discovery Sciences.
* As a laboratory supervisor, a commitment to coaching and guiding professional development is required.

Qualifications

Must-Have

* PhD in Molecular Biology, Biochemistry, Cell Biology, and/or Pharmacology with 10+ years post-degree experience, including industry experience
* Proven ability to build, lead, energize and develop a high-performing team of scientists.
* Demonstrated examples of strong scientific leadership, independent thought and creativity, and ability to integrally contribute to program strategies and execute plans.
* Experience successfully interacting with and meeting the needs of stakeholder groups is essential as well as having a customer focus.
* Demonstrated experience with multiple plate-based pharmacology formats (e.g. FRET, FACS, FP, ELISA, high content imaging, FLIPR, radioligand binding, nanoBRET etc.), mass spectrometry (HTMS, LC-MS, AEMS) including assay development and troubleshooting
* Demonstrated proficiency in laboratory automation and data analysis with excellent computer, verbal and written communication skills
* A strong publication and presentation record showcasing scientific leadership in pharmacology and drug discovery.

Nice-to-Have

* Previous experience in multiple target classes (e.g. GPCRs, transporters, kinases, ion channels, DUBs, RNA) in a drug discovery setting
* Experience with phenotypic screening and hit deconvolution
* Demonstrated ability to forge strong collaborative and inclusive relationships inside and outside organizational walls and across multiple cultures: academic, industrial, and CROs

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

PHYSICAL/MENTAL REQUIREMENTS

Sitting, standing, lifting, bending, and walking. Ability to perform practical laboratory bench work and work on a computer (while standing or sitting). Ability to perform mathematical calculations and interpret data.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

* Travel to attend appropriate meetings and conferences.
* Compliance with laboratory safety practices.

Relocation support available

Work Location Assignment: On Premise

The annual base salary for this position ranges from $161,600.00 to $269,400.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 20.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development