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Associate Research Fellow Drug Product Design
2 months ago
The purpose of this position is to act as a resident pharmaceutical science subject matter expert in spray dried dispersion (SDD) technology. This role will collaborate with formulation scientists to influence small molecule drug candidate selection with respect to application of SDD technology to improve drug delivery and bio-performance. This role will be responsible for development and optimal SDD composition selection as well as characterization to ensure appropriate in vivo performance. As an individual and as part of a network, this role will contribute to the formation of predictive models, efficiency in process and workflows, as well as exploration of more efficient and/or greener amorphous solid dispersion (ASD) manufacturing technologies. This position will perform technology transfer activities with our GMP SDD vendor network.
ROLE RESPONSIBILITIES
Evaluate the physicochemical properties of potential small molecule drug candidates to inform an ASD formulation strategy and developability risk assessment.Design and develop fit for purpose and diagnostic SDD formulations for preclinical studies.Be a subject matter expert in formulation and process development for SDDs supporting multiple discovery teams across several research units.Apply first-principles understanding of thermodynamics and kinetic processes to dissolution and precipitation of drugs in biorelevant conditions as well as physical and chemical stability in the solid state.Develop strategic collaborations with academic and industrial researchers for addressing gaps in fundamental or applied science related to amorphous solid dispersions.Conduct novel research and present significant findings via internal and external presentations or publications.Supervision of laboratory staff to support SDD production and assessment.Work collaboratively with scientists across the organization to understand and address key challenges in the ASD space.
BASIC QUALIFICATIONS
PhD with 12+ years experience in industrial spray dried dispersion technology or related disciplinesExperience in formulation and manufacturing of SDDs targeted at bioavailability enhancementExperience working independently and collaboratively in a laboratory environment
PREFERRED QUALIFICATIONS
Experience in breaking down and isolating the controlling physics of complex processes for experimental designExperience in designing and conducting hypothesis driven laboratory experimentsGenerating, interpreting, and integrating experimental data into mathematical models to progress the understanding of complex materials and processesExperience in pharmacokinetic modeling and simulations using Gastroplus, Simcyp, or Phoenix Strong organizational skills, interpersonal skills, teamwork skills, strong written and verbal communication skillsAbility to prioritize and manage multiple projects and activities while managing tight timelinesCandidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
PHYSICAL/MENTAL REQUIREMENTS
Includes activities in both laboratory and office settings. Candidate must be able to perform routine laboratory tests and procedures. Ability to perform mathematical calculations and ability to perform complex data analysis.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Occasional travel for conferences/training (domestic and international)
Relocation support available
Work Location Assignment:On Premise
The annual base salary for this position ranges from $149,200.00 to $248,600.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 20.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development
