Senior Scientist, In vivo Pharmacology, Discovery Technologies
2 months ago
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
About Loxo@Lilly: Loxo@Lilly aims to create medicines that make life better for all those affected by cancer around the world. Bringing together the focus and spirit of a biotech with the scale, resources, and heritage of Lilly, our team is focused on rapidly delivering impactful new medicines for people with cancer. Our approach centers on creating oncology medicines that unequivocally show early signs of clinical activity and will matter to patients. We intend to curate a balanced pipeline of medicines, either internally or externally discovered, with the potential to treat cancer with dramatic effect. Loxo@Lilly was created in December 2019, combining the Lilly Oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. Loxo@Lilly is a global organization with team members in Louisville, Colorado; Indianapolis, Indiana; New York City, New York; San Diego, California; South San Francisco, California; Stamford, Connecticut; and Madrid, Spain.
Position Summary: The Senior Scientist/Principal Scientist in the Discovery Technologies In vivo Pharmacology group will be part of a dynamic group of scientists conducting various research projects to identify large molecule/biologics which can effectively treat various forms of cancer. The candidate will collaborate with discovery teams in NYC, Indianapolis, San Francisco and Boulder for design and execution of studies. The In vivo Pharmacology Senior Scientist/Principal Scientist will execute experiments, and will also be responsible for performing or collaborating in vivo PK/PD studies done in preclinical models including ex vivo assays (i.e. ELISA based PD read outs). Oversight and/or contribution to ADME work during drug development may be required. The in vivo Pharmacology Senior Scientist/Principal Scientist will report findings directly to both the Loxo scientific and executive leadership, and will be a key member of the discovery organization being responsible for maintaining the scientific quality and efficiency of the organization, as well as assist and guide the strategic direction of the company. The candidate is expected to be a dynamic and motivated scientist who can drive experiments and research activities independently, while collaborating extensively with the entire organization to execute various research programs.
Roles and Responsibilities of the Position:
* Prepare drug solutions and inoculations, multiple route drug administration, animal health monitoring, anesthesia, blood samplings, necropsies, xenografts, syngeneic mouse models, humanized mouse models
* Culture tumor cells according to SOPs and contribute to the development of SOPs
* Work collaboratively with the discovery and clinical teams to support retrospective and exploratory efforts for clinical programs
* Perform cardiac, retro-orbital bleeds, and tumor injections
* Perform tumor measurements using calipers
* Harvest tumor and tissue samples from treated animals to help establish PK/PD and toxicity measurements
* Process blood and tissue samples for monitoring PD markets, hematological and tissue toxicities
* Work with the entire in vivo team to ensure all instrumentation is properly maintained and calibrated
* Proper documentation and archiving of data and analyses
* Work interactively with project teams and discovery teams to plan and execute experiments as well as be involved in data interpretation and preparation of study reports
* Work interactively with project teams as an in vivo pharmacology expert to ensure appropriate applications and priorities are considered
Additional roles and responsibilities:
* Communicate results via written and oral presentations at project team meetings, be involved in the coordination and preparation of presentations
* Discuss results with technical as well as non-technical personnel
* Support archiving as well as curating data in internal databases
* Extensive cross functional communication and collaboration with internal and external parties
* Interrogate experimental conduct of third parties/vendors
Required Qualifications:
* BS degree in biological sciences with 5 years of experience or MS degree in biological sciences with 2-3 years of experience required
* Extensive expertise in: in vivo pharmacology, cell line xenograft establishment, humanized mouse model systems, imaging, standard flow cytometry experiments, bioanalytical functions, small animal handling, carrying out preclinical rodent oncology modeling
Additional Preferences:
* Diverse experience in cell biology and biochemical techniques to monitor PK/PD relationships
* Experience in drug discovery with regulator reporting
* Demonstrated business acumen
* Demonstrated excellence in making key strategic decisions in support of broader business goals
* Excellent written and verbal communication skills
* Flexibility to adjust priorities over time to meet organizational and scientific goals
* Ability to work independently and as an integral part of a larger collaborative team
* Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
* Excellent interpersonal, written, and verbal communication skills
* Knowledge and experience documenting and processing in vivo studies
Physical Demands/ Travel:
TBD
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