Scientist, Medicinal Chemistry

2 weeks ago

San Diego, United States Zentalis Pharmaceuticals Full time

JOB SUMMARY:

We are looking for a creative, resourceful, and highly collaborative laboratory scientist to join our medicinal chemistry team. The candidate will have a strong track record in both cutting edge organic synthesis/ medicinal chemistry, with a demonstrated ability to thrive and contribute in a multi-disciplinary fast-paced environment. The successful candidate will be responsible for the synthesis of small-molecule drug candidates and the analysis of diverse data sets to build structure-activity relationships (SAR) to help drive medicinal chemistry strategy. Proficiency/ experience in the design of new molecules to support SAR and advancement of projects, as well as structure-based design is a plus. We are looking for individuals who have a passion for drug-discovery, and embrace our core values of scientific excellence, high innovation, collaboration, and putting people and patients first.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

* Under general supervision, independently conduct multi-step synthesis of target molecules. Purify and characterize compounds using a variety of techniques including chromatography, crystallization, trituration, LCMS, NMR, etc.
* Independently design and optimize synthetic routes. Solve synthetic chemistry problems to enable access to new chemical space and novel IP.
* Champion the application of cutting-edge modern synthetic chemistry to enable efficient access to complex target molecules at both milligram and multi-gram scale.
* Efficiently analyze complex data sets to develop a deep understanding of SAR. Contribute to the design of new molecules to advance project goals.
* Productively interact with cross-functional scientists (e.g. biology, structural biology, ADME/Tox) to advance project goals. Effectively communicate results and progress in both individual and multi-disciplinary team settings.
* Stay abreast of the literature in both synthetic organic chemistry and medicinal chemistry and proactively apply knowledge to support company research objectives.
* Contribute to the day to day running of the lab to ensure a smooth and safe operation. Maintain a safe working environment and adhere to all corporate lab safety standards.
* Assist in the preparation of patents and publications, as required.
* Maintain excellent record keeping, including updated and well-organized lab e-notebooks.
* Perform other duties as assigned.

EDUCATION/KNOWLEDGE/SKILLS/ABILITIES REQUIRED:

* Ph.D. in synthetic organic or medicinal chemistry required with 0-3 years of relevant industry experience. Academic post-doctoral experience in synthetic/ medicinal chemistry is a plus.
* Strong track record of scientific innovation and problem solving as evidenced by peer-reviewed publications and/or patents. The candidate must exhibit a deep knowledge of modern synthetic chemistry and analytical techniques.
* Experience in synthetic method development and target-oriented synthesis. Experience with chemical biology, structure-based drug design, and/or medicinal chemistry is a plus.
* Self-motivated with excellent interpersonal, organizational and communication skills. Must be able to work effectively in a dynamic and collaborative, fast-paced environment.
* Ability to learn new concepts and skills that support their primary responsibilities in lab.
* Excellent oral and written communication skills, including accurate record keeping and preparation and delivery of presentations/ reports.
* Adaptable/ Flexible - willing and able to adjust to multiple demands and shifting priorities as well as an ability to meet day-to-day challenges with confidence and professionalism.

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