Associate Principal Scientist, Medicinal Chemistry
2 weeks ago
Position summary:
We are seeking a highly motivated chemist with excellent leadership skills and extensive experience working in multi-disciplinary teams (spanning chemistry, biology, analytical sciences, pharmacology, DMPK and toxicology). The successful candidate will lead projects from inception to clinical candidate, as well as mentor other project leads within their chemistry team, and help advance our targeted protein degradation (TPD) platform. Applicants should be experienced drug hunters with a track record of innovation and creative problem solving. The candidate will also manage collaborations and CRO resources as needed. This position will report to the VP of Chemistry and will have direct reports.
Role and responsibilities:
* Responsible for the success of chemistry aspects of the drug discovery teams through individual contributions, and through mentorship of direct reports/ junior colleagues.
* Drive medicinal chemistry efforts simultaneously on multiple projects from the earliest stages through to clinical development.
* Demonstrate expertise in drug design and medicinal chemistry strategies to improve drug-likeness, ADME/DMPK and safety properties.
* Strong laboratory presence- leading from the bench.
* Opportunities for project leadership
* Accountable for providing guidance, direction and contributing to project delivery through the development of people.
* Manage external chemistry CROs.
Required qualifications:
* Ph.D. in synthetic organic chemistry with 8+ years industrial experience (or equivalent).
* High level of creativity and productivity with strong synthetic problem-solving skills, synthetic methods and reactions mechanisms are required.
* The candidate should have deep understanding of molecular properties and DMPK concepts.
* Knowledge and experience in assessing and establishing intellectual property.
* The candidate should have an established interest and passion for new modalities and targeted protein degradation.
* Exceptional interpersonal skills.
Preferred qualifications:
* Experience in custom library generation and experience with novel screening approaches.
What we offer:
* Industry competitive compensation
* Annual target bonus
* Stock options
* 401K plan
* Career advancement opportunities
* Monthly town halls to share business and scientific updates
Work Hard, Stay Well
* Comprehensive medical, dental, and vision plans for employees and their dependents
* Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution
* Employee Assistance Program
* 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave.
* Supplemental pay for Pregnancy Disability Leave
* Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care
Lifestyle
* Casual work environment
* Volunteer days off each year to spend time contributing to causes you care about
* Flexible work schedule
* Access to onsite gym
* Onsite space to store your bicycle (or surfboard)
Have Fun
We believe in work/life balance and Fun is at the core of our Core Values. In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day).
About Us:
Neomorph is a venture backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against 'undruggable targets'. Our team is comprised of industry leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment.
Neomorph is headquartered in San Diego, California, and has a key collaboration with the Center for Protein Degradation at the Dana-Farber Cancer Institute.
Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law.
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