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Senior Research Associate, Process Development
1 month ago
At AstraZeneca's Oncology R&D division, we follow the science to explore and innovate. We are working towards treating, preventing, modifying, and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. We are committed to making a difference and have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs.
Position Summary
We are looking for a motivated, data-driven researcher to join our Process Development (PD) team as a Senior Research Associate. You have a knowledge of basic immunology principles, bioprocess development, and cGMP manufacturing. You should also have experience in primary cell culture (T cells preferred), in different formats including flasks and bags. You will help develop a clinical manufacturing process of engineered T cells with patient-derived neo-antigen specific TCRs. You will also be part of a team involved in implementing technology and participating in technology transfer to the clinical setting.
Responsibilities
- Implement process development studies to develop, scale-up and transfer cGMP manufacturing processes.
- Perform cell culture of T cells in multiple formats including flasks, bags, and bioreactors.
- Collaborate within the project team to interpret study results and contribute to technical discussions for subsequent study design.
- Prepare experimental proposals, technical reports, SOPs and manufacturing batch records.
- Work collaboratively within PD group and with other groups to meet Tech Ops organization goals.
- Other responsibilities as assigned.
Education and Experience
- MS degree in Immunology, Cell Biology, Molecular biology, Bioengineering, or relevant degrees with 1+ years relevant industry experience or BS degree with 2+ years relevant industry experience.
- Experience in technical development of cell and gene therapy or biologics in early and late development setting.
- Hands-on experience in cell and gene therapy, specifically in T cells.
- Experience in Flow Cytometry.
- Knowledge of cGMP manufacturing and regulations and practical experience in GMP operations.
- Knowledge of on board diagnostics (ObD) , design of experiments (DOE) and appropriate statistical analysis for process development.
When we put unexpected teams in the same room, we fuel bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.
The annual base salary for this position ranges from $98,100 to $109,000. However, base pay offered may vary depending on multiple individualized factors, including market location, job-related experience. If hired, employee will be in an 'at-will position' and we reserve the right to modify base salary (and any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.
Benefits
- Short-term incentive bonus opportunity
- Equity-based long-term incentive program
- 401(k) plan
- Paid vacation and holidays; paid leaves
- Health benefits including medical, prescription drug, dental, and vision coverage.
DE&I Statement
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.
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