Principal Scientist, Translational Modeling
3 weeks ago
About the roleThe position is located in Cambridge, MA and will not have the ability to be located remotely.#LI-Hybrid About the role: We are seeking an experienced translational modeler eager to accelerate drug discovery & development by facilitating rigorous decision making with modeling & simulation, from target identification to first-in-human studies and beyond. You will work in a multi-disciplinary environment with opportunities to engage in projects that span different therapeutic modalities. This role reports to a PK Sciences Translational Modeling team lead within Translational Medicine in Biomedical Research. Key responsibilities: • Act as the Translational M&S representative on programs in oncology, developing and executing modeling strategies, contributing to project team discussions, and guiding therapeutic design and dose selection decisions. • Build and apply QSP and physiologically based PK (PBPK) models that link drug pharmacology, tissue biodistribution, mechanism(s) of action, and biological outcomes. • Advance the development of integrated modeling platforms that bridge data and knowledge across preclinical species and patients, partnering with discovery project teams as well as the preclinical safety and pharmacometrics groups. • Contribute to programs across therapeutic modalities and disease indications, as needed. Novartis has a wide portfolio with hundreds of drug discovery and clinical development projects and you will have opportunities to grow and develop as you apply modeling insights to diverse projects. • Proactively seek opportunities to increase the impact and awareness of translational modeling through communications with internal and external audiences. https://www.linkedin.com/posts/novartis_novartis-careers-activity-7167819672107642880-Wh15?utm_source=share&utm_medium=member_desktopEEO Statement We are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please let us know the nature of your request, your contact information and the job requisition number in your message:Novartis: e-mail us.reasonableaccommodations@novartis.com or call +1 (877)395-2339Sandoz: e-mail reasonable.accommodations@sandoz.com or call: +1-609-422-4098Role RequirementsEssential requirements: Ph.D. in biology, pharmaceutical sciences, bioengineering, biophysics, or a related field, or a master’s degree with 4+ years of industry experience. Candidates with a Pharm.D. or background in mathematics or other quantitative fields and a deep understanding of biological concepts will be considered. Prior experience in quantitative systems pharmacology (QSP), pharmacokinetics and pharmacodynamics (PKPD), and/or physiologically based PK (PBPK) modeling is strongly preferred. Expert level proficiency in core modeling fundamentals is required, including scripting languages (e.g., MATLAB, R), construction of ordinary differential equation (ODE) models, parameter estimation, and data visualization. Demonstrated ability to communicate modeling results to a multidisciplinary audience to facilitate strategy and decision-making. Fluent in English (oral and written). #ModelingAndSimulation #PKSciences #TranslationalMedicineQuants Why Novartis: Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us Learn more here: https://www.novartis.com/about/strategy/people-and-culture You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook.https://www.novartis.com/careers/benefits-rewardsCommitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams’ representative of the patients and communities we serve.Accessibility and Reasonable Accommodations: The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to tas.nacomms@novartis.com call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.Novartis Compensation and Benefit Summary: The pay range for this position at commencement of employment is expected to be between $130,400 - $195,600/year; however, while salary ranges are effective from 1/1/24 through 12/31/24, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to learn more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/networkDivisionBiomedical Research Business UnitTranslational Medicine Work LocationCambridge, MA Company/Legal EntityNIBRIFunctional AreaResearch & Development Job TypeFull TimeEmployment TypeRegular Shift WorkNoEarly TalentNoCountry: USA
-
Principal Scientist, Translational Modeling
2 weeks ago
Cambridge, United States Novartis Full time**About the Role**: The position is located in Cambridge, MA and will not have the ability to be located remotely. LI-Hybrid About the role: We are seeking an experienced translational modeler eager to accelerate drug discovery & development by facilitating rigorous decision making with modeling & simulation, from target identification to first-in-human...
-
Cambridge, United States Moderna, Inc. Full timeThe Role:As part of our vision, Moderna is committed to invest in R&D to further expand our impact on patients. You will be part of a growing team in Clinical and Translational Computational Oncology in R&D. The group will be focused on mining the multi-omics data obtained from clinical samples, understanding how the data can explain, predicting clinical...
-
Cambridge, Massachusetts, United States Moderna, Inc. Full timeThe Role:As part of our vision, Moderna is committed to invest in R&D to further expand our impact on patients. You will be part of a growing team in Clinical and Translational Computational Oncology in R&D. The group will be focused on mining the multi-omics data obtained from clinical samples, understanding how the data can explain, predicting clinical...
-
Principal Scientist, Translational Discovery
21 hours ago
Cambridge, United States Bristol Myers Squibb Full timeWorking with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms...
-
Cambridge, United States Biogen Idec Full timeCompany DescriptionJob Description The Translational Neuropathology group at Biogen, part of Translational In-Vivo Science in Research, is seeking a highly motivated and talented scientist to join a dynamic team engaged in human disease translational research and drug development. The scientist will employ cutting-edge histopathologic techniques to develop...
-
Cambridge, United States Biogen Full timeCompany DescriptionJob DescriptionThe Translational Neuropathology group at Biogen, part of Translational In-Vivo Science in Research, is seeking a highly motivated and talented scientist to join a dynamic team engaged in human disease translational research and drug development. The scientist will employ cutting-edge histopathologic techniques to develop...
-
Research Scientist, Discovery and Translational
2 weeks ago
Cambridge, United States Novartis Full time**Summary**: About the role : Internal Job Title: Research Scientist II Job Location: Cambridge, MA onsite About the Role: Disease Area X, a department within the Biomedical Research (BR) group of Novartis, focuses on diseases of critical human organs, including kidney, lung, and liver. We are seeking a scientist to join our interdisciplinary pharmacology...
-
Principal Scientist, Discovery and Translational
2 weeks ago
Cambridge, United States Novartis Full time**Summary**: **About the Role**: About the Role: - Essential Requirements: - Ph.D or MD/Ph.D or equivalent training. - At least 3 years of postdoctoral experience in industry or equivalent. - Pharmacology expertise in renal biology (preferred) and/or general drug discovery. - Team oriented and collaborative work ethic. - Proven ability to coach and empower...
-
Scientist, Translational Pathology
7 days ago
Cambridge, Massachusetts, United States Bristol Myers Squibb Full timeWorking with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the...
-
Scientist, Translational In Vivo Sciences
7 days ago
Cambridge, Massachusetts, United States Biogen Full timeJob DescriptionAbout This Role Translational In Vivo Sciences is seeking a scientist to join a cross-functional research effort to enhance the delivery of Biogen's therapeutics to the central nervous system (CNS) and muscle. These efforts will be applied across multiple therapeutic areas in the neurological and neuromuscular space, supporting portfolio...
-
Cambridge, United States MOMA Therapeutics Full timeJob DescriptionJob DescriptionMOMA Therapeutics is looking for an experienced Sr. Scientist/Principal Scientist, Computational Chemistry About MOMA TherapeuticsUnlocking a new target class in drug discovery is no small task: it requires computation to transform data into insights; it requires scientific and technological excellence; it demands a culture of...
-
Cambridge, Massachusetts, United States MOMA Therapeutics Full timeMOMA Therapeutics is looking for an experienced Sr. Scientist/Principal Scientist, Computational Chemistry About MOMA TherapeuticsUnlocking a new target class in drug discovery is no small task: it requires computation to transform data into insights; it requires scientific and technological excellence; it demands a culture of focus, resilience, creativity,...
-
Principal machine learning scientist
4 days ago
Boston, MA, United States DeepRec.ai Full timeJob Title: Principal ML Scientist Work Arrangement: Hybrid Location: Boston Sponsorship: Available We are seeking a skilled ML Scientist with experience in LLMs to join our team to train & refine advanced models on scientific texts. Working with experts in biology, bioinformatics to help transform scientific research. The perfect candidate has a...
-
Principal Scientist, Protein Analytics
4 days ago
Waltham, MA, United States Dragonfly Therapeutics Full timePrincipal Scientist, Protein Analytics Dragonfly Therapeutics is seeking a Principal scientist who brings enthusiasm, intellectual curiosity, scientific rigor, and a desire to help drive novel immunotherapy programs forward. The candidate must be independent, goal-oriented, flexible, and able to work efficiently across multiple projects. We are searching...
-
Principal Scientist, Immunopeptidomics
6 days ago
Cambridge, United States Johnson & Johnson Full timeJohnson and Johnson is recruiting for a **Principal Scientist, Immunopeptidomics & Proteomics **for our site located in Cambridge, MA. **Primary responsibilities**: - Manage a team of wet lab scientists enabling proteomic insights across a wide variety of programs and therapeutic modalities. - Plan, oversee and perform wet lab proteomic activities for...
-
Principal Scientist, Clinical Biomarker
4 days ago
Boston, MA, United States Meet Recruitment Limited Full timeJob Title: Principal Scientist, Clinical Biomarker Company Overview: Join a dynamic and forward-thinking mid-sized biotech company dedicated to advancing breakthrough therapies and diagnostics in the field of life sciences. Our client's innovative research and collaborative approach drive meaningful progress in healthcare, with a focus on improving...
-
Principal Scientist, Rare Variant Modeling
1 month ago
Cambridge, United States Bristol-Myers Squibb Full time**Working with Us** Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms...
-
Senior Principal Cyber/EW Research Scientist
4 weeks ago
Cambridge, United States Raytheon Technologies Corporation Full timeDate Posted:2024-04-03 Country:United States of America. Location:MA 105: BBN Headquarters 10 Moulton Street , Cambridge, MA, 02138 USA - Position Role Type:Onsite. At Raytheon, the foundation of everything we do is rooted in our values and a highe Research Scientist, Research, Business Development, Principal, Scientist, Cybersecurity, Manufacturing,...
-
Cambridge, United States AbbVie, Inc Full timeCompany Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services...
-
Modeling & Simulation Data Scientist
14 hours ago
Cambridge, United States Dale WorkForce Solutions Full timeClient: BiotechLocation: Hybrid out of Cambridge, MA OR Thousand Oaks, CADuration: 1 year contract + extensionsThe Modeling and Simulation Data Scientist will support the Combination Product Operations organization by improving the way Client manages and utilizes data to enhance data analysis and decision making within the organization. We are seeking a...
