Sr. Scientist/Principal Scientist, Computational Chemistry

2 weeks ago

Cambridge, United States MOMA Therapeutics Full time
Job DescriptionJob Description

MOMA Therapeutics is looking for an experienced Sr. Scientist/Principal Scientist, Computational Chemistry

About MOMA Therapeutics

Unlocking a new target class in drug discovery is no small task: it requires computation to transform data into insights; it requires scientific and technological excellence; it demands a culture of focus, resilience, creativity, and collaboration; and it requires you At MOMA Therapeutics, we are motivated by a single common goal, to discover and develop the next generation of novel precision medicines for patients through our singular focus: the therapeutic targeting of molecular machines.

Imagine joining a company where you...

  • Will be part of an experienced and resilient team that is collectively unstoppable, trusts one another, and selflessly collaborates
  • Will be part of a group comprised of incredible humans who are committed to the discovery of transformative medicines for cancer patients
  • Will be part of a company placing computation as a central pillar of its strategy
  • Are needed… because the work you will do is critical to the success of the company, and because patients are counting on you

Our computational sciences team is looking to expand our expertise in computational chemistry. The computational sciences group is a cross-disciplinary team comprised of computational chemists, computational biologists, data scientists, cheminformaticians, and machine learners deeply embedded in our project teams and making contributions critical to MOMA's mission. In this role, you will have the opportunity to shape the team and learn new areas of computational sciences by wearing many hats and see drug discovery from all angles.

In this role you will...

  • Provide computational chemistry solution to drug discovery programs including building and deploying tools and analyses that impact medicinal chemistry decisions on drug discovery projects, spanning target assessment, hit finding, and lead optimization.
  • Collaborate closely with drug discovery team and other computational scientists to strategize what data to collect to populate the KnowledgeBase, address computational/informatic needs.
  • Explore cutting-edge computational technologies and novel scientific directions that can expand MOMA's KnowledgeBase and accelerate the small molecule design cycle.

About you...

  • You have a PhD degree in computer science, computational chemistry, or related fields with 2+ years relevant drug discovery experience in a pharmaceutical or biotechnology setting. Level will reflect experience.
  • You have deep experience implementing computational chemistry strategies across all stages of drug discovery including target identification, hit identification and optimization to achieve program goals.
  • Proficient in scientific programming and tool development with Python
  • You have demonstrated understanding of all aspects of modern drug discovery including medicinal chemistry, DMPK principles, multi-parameter optimization.
  • In-depth knowledge of quantum mechanics, QM/MM and modeling protein-protein interactions is highly preferred.
  • You work hard, you are kind to others, and you enjoy being a part of a collaborative team that gets stuff done.
  • You enjoy being in an environment where scientific data rules the day.

MOMA Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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