Senior Scientist

3 weeks ago

South San Francisco CA, United States Genentech Full time

The PositionWe advance science so that we all have more time with the people we love.Genentech’s Investigative Toxicology group works to elucidate the mechanisms underlying toxicities observed for our novel therapeutics spanning from drug discovery through clinical development. This process involves close collaboration with scientists across the organization to support the overall safety assessment efforts. The Investigative Toxicology group provides fit-for-purpose wet lab-based experimental approaches to address target safety assessment, lead optimization, and issue mitigation by employing state-of-the-science in vitro and ex vivo approaches. As such, Investigative Toxicology continuously strives to establish new platforms and technologies to support a constantly evolving portfolio, novel modalities, and emerging therapeutic area needs. This requires highly motivated individuals to work in collaboration with other researchers in the Investigative Toxicology lab and across Genentech’s Research and Early Development organization. All members of the Investigative Toxicology group are expected to be proficient in cell culture and the application of essential molecular biology approaches. In addition to assay development and fit for purpose mechanistic studies, this role focuses on the application of novel methodologies to the in vitro and ex vivo studies conducted by Safety Assessment as well as support for routine toxicology assay screening for drug discovery programs. The role interfaces closely with colleagues in Computational Toxicology and Project Team Toxicologists to develop capabilities that enhance our Predictive Safety efforts.We are looking for a highly motivated individual to fill a Scientist position performing laboratory-based research in the Investigative Toxicology group within the Department of Safety Assessment. This Scientist role will primarily provide independent hypothesis-driven research aimed at characterization of potential or identified nonclinical and clinical toxicity issues related to undesired or exaggerated pharmacology. The scientist may supervise and train laboratory technical staff as appropriate. The scientist will interact closely with discovery scientists, toxicologists, and pathologists as necessary to deconvolute toxicology issues and ensure that drug discovery teams consider all appropriate strategic and investigative needs for better lead candidate selection and characterization of toxicology issues at the time of transition to early drug candidate development. Additionally, the scientist will provide strategies and support activities for toxicity issues identified in later stages of the drug development process.The Opportunity:As an integral member of this dynamic team, you will be responsible for establishing, qualifying and implementing innovative and state-of-the-art technologies and platforms to support Safety Assessment including but not limited to: -Providing Safety Assessment duties including but not limited to:Advancing 3D and microphysiological systems (e.g. organ-on-a-chip)iPSC-derived cell modelsLive cell and high-content imaging (e.g., cell painting)Complex genomic and transcriptomic profiling of in vivo/in vitro systems and studiesImplementing comprehensive imaging methodologies/high-content approaches for predictive safety effortsDeveloping and optimizing of cross-species in vitro models to improve translational relevanceIdentifying and characterizing novel safety-related biomarkersGene editing and advanced molecular biology techniques​-Utilizing Technical SkillsIndependently designing and conducting experiments with minimal review/feedback. Ability to interpret data and troubleshoot problems.Proficiency in a broad variety of well-established biochemical and molecular biology skill sets including, but not limited to protein quantification (ELISAs), cell imaging approaches, gene expression analysis, primary cell culture or familiarity with complex in vitro models. Experience with high-content imaging methodologies for toxicology applications is preferred.Independently analyzing data and generate appropriate graphs/images/statistics using software such as Prism, Spotfire, JMP, etc.Responsible for entering data into laboratory notebook records and maintaining associated protocols for the lab; may cross-train other individuals as needed.Maintaining instruments and associated equipment/resources for their area of expertise-Demonstrating Working KnowledgeUnderstanding principles of toxicology in drug discovery and development, including experimental designs to determine mechanisms of toxicity and address program liabilities.Demonstrating skills in the development and application of new assays/technologies for safety-related issues.Strong aptitude for independent thought/creativity in relevant areas of expertise.Excellent working knowledge in at least one key area of focus relevant to safety assessment of pharmaceuticals/biologics.-Communicating/CollaboratingPresenting work to the lab group and department. Presentations are clear with appropriate use of presentation tools. Providing a clear, complete and easily followed record of data acquisition and experimental methodology. Writing documents in their entirety that require little to no revision.Articulating plans to address group/project goals including timeline estimates and required resources.Demonstrating effective teamwork at both the group and department levels.Active participating in lab-wide activities; (e.g. contributes to maintenance of key equipment/process)Successfully partnering with others in the lab as needed to accomplish experimental goals; cross-train others when required.Regularly communicating with managers and collaborators regarding project status, timelines, troubleshooting activities, and deliverables.Who You Are:A PhD in toxicology, pharmacology, cellular or molecular biology, genetics, or related field is required1-3 years relevant post PhD experience or industry experience in the pharmaceutical, biotechnology, or CRO industry related to toxicology is desired.  Relocation benefits are available for this job posting.The expected salary range for this position based on the primary location of South San Francisco, California is $120,700-$224,100.  Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.  A discretionary annual bonus may be available based on individual and Company performance.  This position also qualifies for the benefits detailed at the link provided below.BenefitsGenentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.Job SummaryJob number: 202404-110263Date posted : 2024-05-05Profession: Research & DevelopmentEmployment type: Full time

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