Scientist

3 weeks ago

Framingham, United States TalentBurst, an Inc 5000 company Full time

Industry: Biotechnology

Title: Scientist I, Cell culture

Job ID: SNFIJP00009136

Location: Framingham, MA - 01701

Duration: 12 months contract (+Possibility to extend)


Must Have Skills:

  • Seeking 2-4 years of experience depending on education
  • Must have professional work experience, in biotech/ pharma industry.
  • For MS candidates, we are considering the required years (2-4) as professional work experience only in addition to the degree. For PhD candidates, professional work experience is required.
  • Hands on experience/coursework/knowledge in mammalian cell culture process development:
  • Experience with mammalian cell cultures (Experience with CHO cells, HEK cells, HeLa cells, CAR-T cells or T-cells, etc), therapeutic molecule production (enzymes, monoclonal antibodies, viral vectors, vaccines or cell therapy) and/or upstream process development (batch, fed-batch or perfusion cultures)
  • Coursework/knowledge and preferably past hands-on experience in bioreactor operation (bench scale and/or pilot scale stirred tank bioreactors or wave bioreactors)


Nice to Have:

  • 3+ years of relevant experience
  • Hands on experience/coursework/knowledge in Process Analytical Technology: Experience with sensor technology (spectroscopy, electrochemical, chromatographic or other), PAT applications (process monitoring or process control), etc.
  • Hands on experience/coursework/knowledge in Data Analytics: Potential experience with Statistical, Machine Learning or Deep Learning for regression in predictive models.


Overview:

  • As a scientist, the candidate will contribute to the development, characterization, testing and scale-up/down of automated and PAT (Process Analytical Technology) enabled mammalian cell culture process platforms for biotherapeutic manufacturing.
  • The goal of this position is to advance innovation in our manufacturing capabilities by developing robust, scalable, automated, and data-driven cell culture processes for ***’s diverse early and late-stage biologics pipeline. The candidate will work in a cross-functional environment and in close collaboration with members from the Cell Culture Development, Process Analytical Technology, Data Sciences, Automation Engineering and Bioanalytics teams


Key responsibilities:

  • Develop, characterize, and test an integrated and automated cell culture process platform and associated process strategies through the integration of sensing technology, data analytics and automation.
  • Investigate, design, and independently execute research activities using the aforementioned process platform to improve cell culture process performance (productivity and/or product quality), optimize platform workflows and deepen scientific understanding of cell culture production systems.
  • Critically evaluate relevant scientific, technological, and regulatory literature to advance the proposed platform and its impact in our early and late-stage biologics pipeline.
  • Lead efforts for industrialization and technology transfer of proposed automated cell culture process platform and associated process strategies within ***.
  • Responsible for planning, executing, documenting, and interpreting experimental work and results with appropriate supervision and documentation.
  • Author high quality scientific and operational documentation and deliver scientific presentations.


Basic qualifications:

  • Master’s degree (2-4 years) or PhD degree (0-2 years) in Biotechnology, (Bio)Chemical engineering, Biology, Biochemistry, or a related field.
  • Relevant knowledge, coursework and/or hands-on experience in mammalian cell culture process development (e.g., cell biology and biochemistry, cell culture engineering, recombinant protein production, bioreactor engineering, protein product characterization, sterility and aseptic techniques, technology transfer, etc.).
  • Strong motivation, curiosity, attention to detail, multitasking ability and active problem-solving and troubleshooting skills.
  • Ability to work both independently and in a team-oriented environment with strong project management and communication skills (oral/written).


Preferred Qualifications:

  • Relevant knowledge, coursework and/or hands-on experience in Process Analytical Technology (PAT), its applications (process monitoring, control, and supervision) and/or in-line/on-line sensing technology (e.g. Spectroscopy, Optical, Enzymatic, Chromatographic sensors, etc.)
  • Knowledge, coursework and/or hands-on experience in process data analytics (multivariate, time series and/or signal processing through statistical/machine learning methods).

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