Scientist

2 days ago

Framingham, Massachusetts, United States Artech LLC Full time
Job Title: Scientist

Duration: 12 Months

Location: Framingham, MA


Job Description:

As a scientist at Artech LLC, you will contribute to the development, characterization, testing, and scale-up/down of automated and PAT-enabled mammalian cell culture process platforms for biotherapeutic manufacturing. Your goal will be to advance innovation in our manufacturing capabilities by developing robust, scalable, automated, and data-driven cell culture processes for our diverse early and late-stage biologics pipeline.

The candidate will work in a cross-functional environment and in close collaboration with members from the Cell Culture Development, Process Analytical Technology, Data Sciences, Automation Engineering, and Bioanalytics teams at Artech LLC.

Key Responsibilities:
  • Develop, characterize, and test an integrated and automated cell culture process platform and associated process strategies through the integration of sensing technology, data analytics, and automation.
  • Investigate, design, and independently execute research activities using the aforementioned process platform to improve cell culture process performance (productivity and/or product quality), optimize platform workflows, and deepen scientific understanding of cell culture production systems.
  • Critically evaluate relevant scientific, technological, and regulatory literature to advance the proposed platform and its impact in our early and late-stage biologics pipeline.
  • Lead efforts for industrialization and technology transfer of proposed automated cell culture process platform and associated process strategies within Artech LLC.
  • Responsible for planning, executing, documenting, and interpreting experimental work and results with appropriate supervision and documentation.
  • Author high-quality scientific and operational documentation and deliver scientific presentations.
Basic Qualifications:
  • Master's degree (2-4 years) or PhD degree (0-2 years) in Biotechnology, (Bio)Chemical engineering, Biology, Biochemistry, or a related field.
  • Relevant knowledge, coursework, and/or hands-on experience in mammalian cell culture process development (e.g., cell biology and biochemistry, cell culture engineering, recombinant protein production, bioreactor engineering, protein product characterization, sterility, and aseptic techniques, technology transfer, etc.).
  • Strong motivation, curiosity, attention to detail, multitasking ability, and active problem-solving and troubleshooting skills.
  • Ability to work both independently and in a team-oriented environment with strong project management and communication skills (oral/written).
Preferred Qualifications:
  • Relevant knowledge, coursework, and/or hands-on experience in Process Analytical Technology (PAT), its applications (process monitoring, control, and supervision) and/or in-line/on-line sensing technology (e.g., Spectroscopy, Optical, Enzymatic, Chromatographic sensors, etc.).
  • Knowledge, coursework, and/or hands-on experience in process data analytics (multivariate, time series, and/or signal processing through statistical/machine learning methods).

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