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Scientist

2 months ago

Framingham, United States Artech LLC Full time
Job Title: Scientist
Duration: 12 Months
Location: Framingham, MA

Job Description:
As a scientist, the candidate will contribute to the development, characterization, testing and scale-up/down of automated and PAT (Process Analytical Technology) enabled mammalian cell culture process platforms for biotherapeutic manufacturing. The goal of this position is to advance innovation in our manufacturing capabilities by developing robust, scalable, automated, and data-driven cell culture processes for Client’s diverse early and late-stage biologics pipeline. The candidate will work in a cross-functional environment and in close collaboration with members from the Cell Culture Development, Process Analytical Technology, Data Sciences, Automation Engineering and Bioanalytics teams at Client.

Key responsibilities
  • Develop, characterize, and test an integrated and automated cell culture process platform and associated process strategies through the integration of sensing technology, data analytics and automation.
  • Investigate, design, and independently execute research activities using the aforementioned process platform to improve cell culture process performance (productivity and/or product quality), optimize platform workflows and deepen scientific understanding of cell culture production systems.
  • Critically evaluate relevant scientific, technological, and regulatory literature to advance the proposed platform and its impact in our early and late-stage biologics pipeline.
  • Lead efforts for industrialization and technology transfer of proposed automated cell culture process platform and associated process strategies within Client.
  • Responsible for planning, executing, documenting, and interpreting experimental work and results with appropriate supervision and documentation.
  • Author high quality scientific and operational documentation and deliver scientific presentations.

Basic qualifications
  • Master’s degree (2-4 years) or PhD degree (0-2 years) in Biotechnology, (Bio)Chemical engineering, Biology, Biochemistry, or a related field.
  • Relevant knowledge, coursework and/or hands-on experience in mammalian cell culture process development (e.g., cell biology and biochemistry, cell culture engineering, recombinant protein production, bioreactor engineering, protein product characterization, sterility and aseptic techniques, technology transfer, etc.).
  • Strong motivation, curiosity, attention to detail, multitasking ability and active problem-solving and troubleshooting skills.
  • Ability to work both independently and in a team-oriented environment with strong project management and communication skills (oral/written).
Preferred Qualifications
  • Relevant knowledge, coursework and/or hands-on experience in Process Analytical Technology (PAT), its applications (process monitoring, control, and supervision) and/or in-line/on-line sensing technology (e.g. Spectroscopy, Optical, Enzymatic, Chromatographic sensors, etc.)
  • Knowledge, coursework and/or hands-on experience in process data analytics (multivariate, time series and/or signal processing through statistical/machine learning method